Accession
MI0003130
Symbol
HGNC:
MIR202
Description
Homo sapiens
hsa-mir-202 precursor miRNA mir-202
Gene
family?
family?
RF00705;
mir-202
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR202 is a microRNA that has been studied in various contexts. It has been found to have both upregulated and downregulated expression in different studies [PMC9967215]. MIR202 has been proposed as a potential biomarker for breast cancer, as it has been identified in multiple independent clinical studies [PMC9967215]. In eutherian genomes, the MIR202 gene is found closest to the end of the chromosome [PMC3706607]. In knockout (KO) and knock-in (KI) mice, MIR202 expression levels have been shown to decrease [PMC10001410]. MIR202 is downregulated in both KO and KI mice, suggesting its potential role as a regulator [PMC10001410]. Polymorphisms in the MIR202 gene have also been analyzed in B-cell acute lymphoblastic leukemia patients [PMC7421781]. Additionally, MIR202 has been found to be a potential regulator of the hyaluronan synthase-encoding gene HAS2, which is associated with aging and angiogenesis [PMC4168028]. The expression of MIR202 has also been studied in wound healing and esophageal cancer cells [PMC8575992] [PMC5302951]. It is worth noting that miR-181c, miR-19a, miR-503, and miR-105 are involved in brain metastasis of breast cancer but are not directly related to MIR202.
Literature search
64 open access papers mention hsa-mir-202
(285 sentences)
(285 sentences)
Sequence
30687
reads,
1373
reads per million, 89 experiments
cgccucagagccgcccgccguuccuuuUUCCUAUGCAUAUACUUCUUUGaggaucuggccuaaAGAGGUAUAGGGCAUGGGAAaacggggcggucggguccuccccagcg
(((....(((..((((((((((((.(((((((((((.(((((((((((.(((......))))))))))))))..))))))))))).))))))).))))).)))....)))
(((....(((..((((((((((((.(((((((((((.(((((((((((.(((......))))))))))))))..))))))))))).))))))).))))).)))....)))
Structure
cuca cc - u -A G au cgc gag gcccg ccguucc uuUUCCUAUGC UAUACUUCUUU agg c ||| ||| ||||| ||||||| ||||||||||| ||||||||||| ||| gcg cuc ugggc ggcgggg aaAAGGGUACG AUAUGGAGAaa ucc u accc -c u c GG - gg
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr10: 133247511-133247620 [-]
Disease association
hsa-mir-202 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-202-5p
| Accession | MIMAT0002810 |
| Description | Homo sapiens hsa-miR-202-5p mature miRNA |
| Sequence | 28 - UUCCUAUGCAUAUACUUCUUUG - 49 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-202-3p
| Accession | MIMAT0002811 |
| Description | Homo sapiens hsa-miR-202-3p mature miRNA |
| Sequence | 64 - AGAGGUAUAGGGCAUGGGAA - 83 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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