miRBase entry: hsa-mir-202

Stem-loop hsa-mir-202

Homo sapiens hsa-mir-202 precursor miRNA
Gene family
MIPF0000121; mir-202

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR202 is a microRNA that has been studied in various contexts. It has been found to have both upregulated and downregulated expression in different studies [PMC9967215]. MIR202 has been proposed as a potential biomarker for breast cancer, as it has been identified in multiple independent clinical studies [PMC9967215]. In eutherian genomes, the MIR202 gene is found closest to the end of the chromosome [PMC3706607]. In knockout (KO) and knock-in (KI) mice, MIR202 expression levels have been shown to decrease [PMC10001410]. MIR202 is downregulated in both KO and KI mice, suggesting its potential role as a regulator [PMC10001410]. Polymorphisms in the MIR202 gene have also been analyzed in B-cell acute lymphoblastic leukemia patients [PMC7421781]. Additionally, MIR202 has been found to be a potential regulator of the hyaluronan synthase-encoding gene HAS2, which is associated with aging and angiogenesis [PMC4168028]. The expression of MIR202 has also been studied in wound healing and esophageal cancer cells [PMC8575992] [PMC5302951]. It is worth noting that miR-181c, miR-19a, miR-503, and miR-105 are involved in brain metastasis of breast cancer but are not directly related to MIR202.

Literature search
64 open access papers mention hsa-mir-202
(285 sentences)


30687 reads, 1373 reads per million, 89 experiments

   cuca   cc     -       u           -A           G   au 
cgc    gag  gcccg ccguucc uuUUCCUAUGC  UAUACUUCUUU agg  c
|||    |||  ||||| ||||||| |||||||||||  ||||||||||| |||   
gcg    cuc  ugggc ggcgggg aaAAGGGUACG  AUAUGGAGAaa ucc  u
   accc   -c     u       c           GG           -   gg 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr10: 133247511-133247620 [-]

Disease association
hsa-mir-202 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-202-5p

Accession MIMAT0002810
Description Homo sapiens hsa-miR-202-5p mature miRNA
Evidence experimental
array-cloned [1], cloned [2]
Database links
Predicted targets

Mature hsa-miR-202-3p

Accession MIMAT0002811
Description Homo sapiens hsa-miR-202-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770