Stem-loop hsa-mir-493

Accession

MI0003132

Symbol

HGNC: MIR493

Description

Homo sapiens hsa-mir-493 precursor miRNA mir-493

Gene
family

RF04100; mir-493

Literature search

36 open access papers mention hsa-mir-493
(272 sentences)

Sequence

5046 reads, 96 reads per million, 85 experiments

cuggccuccagggcuUUGUACAUGGUAGGCUUUCAUUcauucguuugcacauucggUGAAGGUCUACUGUGUGCCAGGcccugugccag
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))

Structure

     cuc        U                    cauucgu 
cuggc   cagggcuU GUACAUGGUAGGCUUUCAUU       u
|||||   |||||||| ||||||||||||||||||||       u
gaccg   gucccGGA CGUGUGUCAUCUGGAAGUgg       g
     --u        C                    cuuacac 

Annotation confidence High

Comments

The mature miRNA sequences were named miR-493-5p and miR-493-3p in [1,2] and here. Landgraf et al. showed that the 3' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr14: 100869060-100869148 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-493

Disease association

hsa-mir-493 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-493-5p

• Accession: MIMAT0002813
• Description: Homo sapiens hsa-miR-493-5p mature miRNA
• Sequence: 16 - UUGUACAUGGUAGGCUUUCAUU - 37
• Evidence: experimental ; array-cloned [1], cloned [2-3]

Mature hsa-miR-493-3p

• Accession: MIMAT0003161
• Description: Homo sapiens hsa-miR-493-3p mature miRNA
• Sequence: 57 - UGAAGGUCUACUGUGUGCCAGG - 78
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267