Accession
MI0003132
Symbol
HGNC:
MIR493
Description
Homo sapiens
hsa-mir-493 precursor miRNA mir-493
Gene
family?
family?
RF04100;
mir-493
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR493 is a down-regulated miRNA in breast cancer (BC) [PMC3828615]. It is also an upregulated oncogenic miRNA in various cancers [PMC9775527]. Deletion of its target gene, CNTN1, leads to a phenotype similar to Temple syndrome [PMC5886287]. MIR493 is part of the DLK1-DIO3 locus and belongs to cluster A [PMC7308478]. It is one of the most strongly differentially expressed (DE) miRNAs in the AF+AVBvsCTL and AFvsCTL analyses in dogs [PMC8376273]. References: - [PMC3828615]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828615/ - [PMC9775527]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775527/ - [PMC5886287]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886287/ - [PMC7308478]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308478/ - [PMC8376273]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376273/
Literature search
36 open access papers mention hsa-mir-493
(272 sentences)
(272 sentences)
Sequence
5046
reads,
96
reads per million, 85 experiments
cuggccuccagggcuUUGUACAUGGUAGGCUUUCAUUcauucguuugcacauucggUGAAGGUCUACUGUGUGCCAGGcccugugccag
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))
Structure
cuc U cauucgu
cuggc cagggcuU GUACAUGGUAGGCUUUCAUU u
||||| |||||||| |||||||||||||||||||| u
gaccg gucccGGA CGUGUGUCAUCUGGAAGUgg g
--u C cuuacac
Annotation confidence
High
Do you think this miRNA is real?
Comments
The mature miRNA sequences were named miR-493-5p and miR-493-3p in [1,2] and here. Landgraf et al. showed that the 3' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr14: 100869060-100869148 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-493
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-493 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-493-5p
| Accession | MIMAT0002813 |
| Description | Homo sapiens hsa-miR-493-5p mature miRNA |
| Sequence | 16 - UUGUACAUGGUAGGCUUUCAUU - 37 |
| Evidence |
experimental
array-cloned [1], cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-493-3p
| Accession | MIMAT0003161 |
| Description | Homo sapiens hsa-miR-493-3p mature miRNA |
| Sequence | 57 - UGAAGGUCUACUGUGUGCCAGG - 78 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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