Stem-loop hsa-mir-496

Accession

MI0003136

Symbol

HGNC: MIR496

Description

Homo sapiens hsa-mir-496 precursor miRNA

Literature search

49 open access papers mention hsa-mir-496
(171 sentences)

Sequence

878 reads, 4.0 reads per million, 85 experiments

cccaagucagguacucgaauggaGGUUGUCCAUGGUGUGUUCAUUUuauuuaugaUGAGUAUUACAUGGCCAAUCUCcuuucgguacucaauucuucuuggg
((((((...(((((.((((.((((((((.(((((..(((((((((........)))))))))..))))).)))))))).)))))))))........))))))

Structure

      -----uca     u    u        U     GU         Uua 
cccaag        gguac cgaa ggaGGUUG CCAUG  GUGUUCAUU   u
||||||        ||||| |||| |||||||| |||||  |||||||||    
ggguuc        ucaug gcuu cCUCUAAC GGUAC  UAUGAGUag   u
      uucuuaac     -    u        C     AU         uau 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations. miR-496 cloned in [2] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.

Genome context

chr14: 101060573-101060674 [+]

Clustered miRNAs

14 other miRNAs are < 10 kb from hsa-mir-496

Disease association

hsa-mir-496 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-496-5p

• Accession: MIMAT0050500
• Description: Homo sapiens hsa-miR-496-5p mature miRNA
• Sequence: 24 - GGUUGUCCAUGGUGUGUUCAUUU - 46
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-496-3p

• Accession: MIMAT0002818
• Description: Homo sapiens hsa-miR-496-3p mature miRNA
• Sequence: 56 - UGAGUAUUACAUGGCCAAUCUC - 77
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770