Stem-loop hsa-mir-520c

Accession

MI0003158

Symbol

HGNC: MIR520C

Description

Homo sapiens hsa-mir-520c precursor miRNA

Literature search

62 open access papers mention hsa-mir-520c
(330 sentences)

Sequence

155 reads, 4 reads per million, 18 experiments

ucucaggcugucgucCUCUAGAGGGAAGCACUUUCUGuugucugaaagaaaagAAAGUGCUUCCUUUUAGAGGGUuaccguuugaga
((((((((.((..(((((((((((((((((((((((....(((...)))..)))))))))))))))))))))))..)).))))))))

Structure

        u  cg                       Guug   g 
ucucaggc gu  ucCUCUAGAGGGAAGCACUUUCU    ucu  
|||||||| ||  |||||||||||||||||||||||    ||| a
agaguuug ca  GGGAGAUUUUCCUUCGUGAAAga    aga  
        c  uU                       --aa   a 

Annotation confidence High

Comments

The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor [2], leading to the -5p, -3p designations. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr19: 53707453-53707539 [+]

Clustered miRNAs

11 other miRNAs are < 10 kb from hsa-mir-520c

Disease association

hsa-mir-520c is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-520c-5p

• Accession: MIMAT0005455
• Description: Homo sapiens hsa-miR-520c-5p mature miRNA
• Sequence: 16 - CUCUAGAGGGAAGCACUUUCUG - 37
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-520c-3p

• Accession: MIMAT0002846
• Description: Homo sapiens hsa-miR-520c-3p mature miRNA
• Sequence: 54 - AAAGUGCUUCCUUUUAGAGGGU - 75
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770