miRBase entry: hsa-mir-516a-1

Stem-loop hsa-mir-516a-1

Accession

MI0003180

Symbol

HGNC: MIR516A1

Description

Homo sapiens hsa-mir-516a-1 precursor miRNA mir-515

Gene
family?

RF00639; mir-515

Literature search

25 open access papers mention hsa-mir-516a-1
(67 sentences)

Sequence

337 reads, 5.0 reads per million, 53 experiments

ucucaggcugugaccUUCUCGAGGAAAGAAGCACUUUCUguugucugaaagaaaagAAAGUGCUUCCUUUCAGAGGGUuacgguuugaga
(((((((((((((((((((.((((...((((((((((((....(((...)))..)))))))))))))))).)))))))))))))))))))

Structure

                   C    AAA            guug   g 
ucucaggcugugaccUUCU GAGG   GAAGCACUUUCU    ucu  
||||||||||||||||||| ||||   ||||||||||||    ||| a
agaguuuggcauUGGGAGA UUUC   CUUCGUGAAAga    aga  
                   C    ---            --aa   a

Annotation confidence Medium

Do you think this miRNA is real?

Genome context

chr19: 53756741-53756830 [+]

Clustered miRNAs

7 other miRNAs are < 10 kb from hsa-mir-516a-1

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

hsa-mir-516a-1 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature hsa-miR-516a-5p

Accession	MIMAT0004770
Description	Homo sapiens hsa-miR-516a-5p mature miRNA
Sequence	16 - UUCUCGAGGAAAGAAGCACUUUCU - 39
Evidence	experimental cloned [2]
Database links
Predicted targets

Mature hsa-miR-516a-3p

Accession	MIMAT0006778
Description	Homo sapiens hsa-miR-516a-3p mature miRNA
Sequence	57 - AAAGUGCUUCCUUUCAGAGGGU - 78
Evidence	experimental array-cloned [1]

References

PubMed ID: 17604727
A mammalian microRNA expression atlas based on small RNA library sequencing
"Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
"Cell (2007) 129:1401-1414

PubMed ID: 15965474
Identification of hundreds of conserved and nonconserved human microRNAs
"Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
"Nat Genet (2005) 37:766-770