miRBase entry: hsa-mir-450a-2

Stem-loop hsa-mir-450a-2


Accession
MI0003187
Symbol
HGNC: MIR450A2
Description
Homo sapiens hsa-mir-450a-2 precursor miRNA mir-450
Gene
family?
RF00708; mir-450

Literature search
21 open access papers mention hsa-mir-450a-2
(43 sentences)

Sequence

23128 reads, 847 reads per million, 112 experiments
ccaaagaaagaugcuaaacuauUUUUGCGAUGUGUUCCUAAUAUguaauauaaauguAUUGGGGACAUUUUGCAUUCAUaguuuuguaucaauaauaugg
.........(((((.(((((((...(((((.(((((((((((((((.......))))))))))))))).)))))...))))))).)))))..........

Structure
-ccaaagaaa     u       UUU     U               aa 
          gaugc aaacuau   UGCGA GUGUUCCUAAUAUgu  u
          ||||| |||||||   ||||| |||||||||||||||  a
          cuaug uuugaUA   ACGUU UACAGGGGUUAugua  u
gguauaauaa     u       CUU     U               aa 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chrX: 134540508-134540607 [-]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-450a-2
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-450a-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-450a-5p

Accession MIMAT0001545
Description Homo sapiens hsa-miR-450a-5p mature miRNA
Sequence 23 - UUUUGCGAUGUGUUCCUAAUAU - 44
Evidence experimental
array-cloned [1,3], cloned [1,4]
Database links
Predicted targets

Mature hsa-miR-450a-2-3p

Accession MIMAT0031074
Description Homo sapiens hsa-miR-450a-2-3p mature miRNA
Sequence 58 - AUUGGGGACAUUUUGCAUUCAU - 79
Evidence not_experimental
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  4. PubMed ID: 15735639
    Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
    "Nature (2005) 434:338-345