Stem-loop hsa-mir-503

Accession

MI0003188

Symbol

HGNC: MIR503

Description

Homo sapiens hsa-mir-503 precursor miRNA mir-503

Gene
family

RF00753; mir-503

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR503 is a microRNA that has been identified as having a significant role in cellular processes, as evidenced by its consistent up- or downregulation across all passages in a study of pHPL-ASC gene expression profiles [PMC6694630]. This microRNA, along with others, is part of a unique gene expression signature that is passage-specific, indicating its potential importance in cellular aging or response to culture conditions [PMC6694630]. Furthermore, MIR503 has been found to be significantly downregulated in tumor samples from esophageal squamous cell carcinoma (ESCC) patients when compared to adjacent non-tumorous tissues from the same patients, with this decrease observed in 83% of the cases studied [PMC5487524]. This suggests that MIR503 may play a role in the tumorigenesis of ESCC or could potentially serve as a biomarker for this type of cancer [PMC5487524]. Additionally, MIR503 is part of the 3′ fragment along with mir351 when mir322 is cleaved; this could influence the biological functions and fate of these microRNA fragments [PMC4057207]. The study of MIR503 and its associated gene expression could provide valuable insights into cancer biology and potential therapeutic targets.

Literature search

113 open access papers mention hsa-mir-503
(881 sentences)

Sequence

45931 reads, 405 reads per million, 115 experiments

ugcccUAGCAGCGGGAACAGUUCUGCAGugagcgaucggugcucuGGGGUAUUGUUUCCGCUGCCAGGgua
((((((.((((((((((((((.((.((..(((((.....))))))).)).)))))))))))))).))))))

Structure

      A              U  G  Gu     a 
ugcccU GCAGCGGGAACAGU CU CA  gagcg u
|||||| |||||||||||||| || ||  ||||| c
augGGA CGUCGCCUUUGUUA GG Gu  cucgu g
      C              U  G  --     g 

Annotation confidence High

Genome context

chrX: 134546328-134546398 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-503

Disease association

hsa-mir-503 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-503-5p

• Accession: MIMAT0002874
• Description: Homo sapiens hsa-miR-503-5p mature miRNA
• Sequence: 6 - UAGCAGCGGGAACAGUUCUGCAG - 28
• Evidence: experimental ; array-cloned [1], cloned [2-3], SOLiD [4]

Mature hsa-miR-503-3p

• Accession: MIMAT0022925
• Description: Homo sapiens hsa-miR-503-3p mature miRNA
• Sequence: 46 - GGGGUAUUGUUUCCGCUGCCAGG - 68
• Evidence: experimental ; SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


4. PubMed ID: 22282338
   Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
   "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
   "RNA (2012) 18:472-484