miRBase entry: hsa-mir-505

Stem-loop hsa-mir-505

Homo sapiens hsa-mir-505 precursor miRNA
Gene family
MIPF0000217; mir-505

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR505 is a microRNA that has been studied in various contexts. It has been used in the 2−ΔΔCT method to normalize gene expression [PMC6352865]. MIR505 is particularly amenable to detection in human fluids [PMC6281605]. In the context of Parkinson's disease (PD), MIR505 has been found to be down-regulated in cerebrospinal fluid (CSF) and brain tissue of PD patients [PMC6115491]. It has also been implicated in ovarian aging, as its expression was induced in both mice and humans [PMC9918015]. MIR505 is involved in various biological processes, such as neural tube formation and cell growth, by targeting genes like fibroblast growth factor 18 (FGF18) and mitogen-activated protein kinase kinase kinase 3 (MAP3K3) [PMC7040864]. Altered expression of MIR505 may be associated with spina bifida and neural tube defects [PMC7040864]. Additionally, MIR505 has been found to be up-regulated along with other miRNAs like miR199a/b and miR320, leading to decreased sensitivity to cisplatin and OXA through modulation of the Wnt/β-catenin pathway [PMC9331520]. The location of MIR505 is upstream of the gene that encodes the ATP11C protein [PMC4561498]. In wheat, MIR505 is one of the miRNAs that could not be detected using Northern blot analysis but was validated by semi-quantitative RT-PCR [PMC2394755].

Literature search
33 open access papers mention hsa-mir-505
(194 sentences)


22821 reads, 422 reads per million, 156 experiments

     ac    u           G    A        ucug 
gaugc  ccag ggGGGAGCCAG AAGU UUGAUGUu    c
|||||  |||| ||||||||||| |||| ||||||||    c
cuacg  gguc cUCCUUUGGUC UUCA AACUGCga    a
     -a    u           G    C        uuug 

Annotation confidence Not enough data
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chrX: 139924148-139924231 [-]

Disease association
hsa-mir-505 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-505-5p

Accession MIMAT0004776
Description Homo sapiens hsa-miR-505-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-505-3p

Accession MIMAT0002876
Description Homo sapiens hsa-miR-505-3p mature miRNA
Evidence experimental
array-cloned [1], cloned [2-3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770