miRBase entry: hsa-mir-532

Stem-loop hsa-mir-532

Homo sapiens hsa-mir-532 precursor miRNA
Gene family
MIPF0000113; mir-188

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR532 is a microRNA that has been found to be significantly up-regulated in a high percentage of hepatocellular carcinoma (HCC) patients who are positive for hepatitis C virus (HCV) [PMC3245605]. No single nucleotide polymorphisms (SNPs) have been identified for MIR532 [PMC6195525]. MIR532 has been used as a normalizer in miRNA expression studies [PMC7266158]. Interestingly, MIR532 has been shown to inhibit the invasiveness of tumor cells, while miR500A, which is located upstream of MIR532, increases tumor invasion [PMC8253104]. MIR532 acts as a tumor suppressor by inhibiting the expression of TERT in ovarian cancer, leading to decreased cell proliferation and lower invasion capacity [PMC8253104]. TERT directly interacts with the upstream region of miR500A but fails to bind the upstream sequence of MIR532, which also contains TBE sequences [PMC8253104]. In ovarian cancer patients, high expression levels of MIR502 and MIR532 have been correlated with overall survival outcome [PMC7359466]. Exosomal MIR532 has also shown prognostic value and is associated with favorable overall survival in acute myeloid leukemia patients [PMC7912829]. The regulation characteristics between the promoters of CLCN5 and MIR532 are distinct, with TTF-1 playing a role in activating the MIR532 promoter but not the CLCN5 promoter [PMC5497805].

Literature search
51 open access papers mention hsa-mir-532
(187 sentences)


63669 reads, 406 reads per million, 133 experiments

cgacuu    u    c  c  U      A    A   CC  uggca 
      gcuu cucu cu CA GCCUUG GUGU GGA  GU     u
      |||| |||| || || |||||| |||| |||  ||     c
      cgag gaga gA GU CGGAAC CACA CCU  ca     u
----uc    c    a  C  U      C    C   CC  uuaau 

Annotation confidence High
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Genome context
chrX: 50003148-50003238 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-532
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-532 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-532-5p

Accession MIMAT0002888
Description Homo sapiens hsa-miR-532-5p mature miRNA
Evidence experimental
PCR [1], cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-532-3p

Accession MIMAT0004780
Description Homo sapiens hsa-miR-532-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  3. PCR-based expression analysis and identification of microRNAs
    "Lu DP, Read RL, Humphreys DT, Battah FM, Martin DIK, Rasko JEJ"
    "RNAi and Gene Silencing (2005) 1:44-49