miRBase entry: hsa-mir-545

Stem-loop hsa-mir-545

Homo sapiens hsa-mir-545 precursor miRNA
Gene family
MIPF0000098; mir-95

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR545 is a pre-mir that has been linked to cell proliferation in colorectal cancer [PMC7199595]. It has been found to be upregulated in endometrial cancer [PMC7199595]. No miRNA prediction binding site tool has identified a statistically supported connection between MIR545 and GPR161 [PMC7199595]. However, it is suggested that both GPR161 and MIR545 may be involved in promoting cell proliferation in UCEC [PMC7199595]. In cervical cancer (CC), it has been found that circ_0067934 interacts with MIR545 as a sponge, inhibiting its expression level [PMC9260044]. Both MIR545 and EIF3C genes are potential gene therapy targets for CC [PMC9260044]. In Lewis Lung Carcinoma cell lines, overexpressed MIR545 inhibits Ku70 activity, suggesting its role in radioresistance [PMC4453103]. The upregulation of MIR545 is HBx-dependent [PMC9280728]. In pancreatic ductal adenocarcinoma, MIR545 directly targets RIG-I, a regulator of antiviral response [PMC6370596]. In experiments testing miRNA mimics, MIR545 was used as a negative control with no observed phenotype compared to mock transfected cells or control siRNA transfected cells [PMC7801944]. Additionally, it has been found that ESRRG is a potential target gene of miR-545/374a and its expression is inversely related to the expression of MIR545[ PMC8789654]..
Overall, the research suggests that MIR545 plays important roles in cell proliferation and radioresistance in various cancers.

Literature search
11 open access papers mention hsa-mir-545
(18 sentences)


4665 reads, 223 reads per million, 57 experiments

cccag    - -----   a         - U            A  A     auaaa 
     ccug g     cac uuaguaggc c CAGUAAAUGUUU UU GAUGA     u
     |||| |     ||| ||||||||| | |||||||||||| || |||||     g
     ggac c     gug aaucgucCG G GUUAUUUACAAA GA CUacu     a
-----    a cucga   a         U U            C  -     cagua 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chrX: 74287104-74287209 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-545
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-545 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-545-5p

Accession MIMAT0004785
Description Homo sapiens hsa-miR-545-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-545-3p

Accession MIMAT0003165
Description Homo sapiens hsa-miR-545-3p mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267