Stem-loop mmu-mir-541

Accession

MI0003521

Symbol

MGI: Mir541

Description

Mus musculus mmu-mir-541 precursor miRNA mir-541

Gene
family

RF00777; mir-541

Literature search

11 open access papers mention mmu-mir-541
(73 sentences)

Sequence

610764 reads, 1434 reads per million, 99 experiments

gccaaaaucagagAAGGGAUUCUGAUGUUGGUCACACUccaagaguuuuaaaaugagUGGCGAACACAGAAUCCAUACUcugcuuauggc
((((.((.(((((...((((((((.((((.(((((((((...))))..........))))).))))))))))))...))))).)).))))

Structure

    a  u     AAG        A    G     ----------    c 
gcca aa cagag   GGAUUCUG UGUU GUCAC          ACUc  
|||| || |||||   |||||||| |||| |||||          |||| a
cggu uu gucUC   CCUAAGAC ACAA CGGUg          ugag  
    a  c     AUA        -    G     aguaaaauuu    a 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr12: 109742409-109742498 [+]

Clustered miRNAs

13 other miRNAs are < 10 kb from mmu-mir-541

Mature mmu-miR-541-5p

• Accession: MIMAT0003170
• Description: Mus musculus mmu-miR-541-5p mature miRNA
• Sequence: 14 - AAGGGAUUCUGAUGUUGGUCACACU - 38
• Evidence: experimental ; cloned [1,3], miRAP-cloned [2], Illumina [4]

Mature mmu-miR-541-3p

• Accession: MIMAT0017209
• Description: Mus musculus mmu-miR-541-3p mature miRNA
• Sequence: 58 - UGGCGAACACAGAAUCCAUACU - 79
• Evidence: experimental ; Illumina [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


5. PubMed ID: 16973894
   Mouse microRNA profiles determined with a new and sensitive cloning method
   "Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H"
   "Nucleic Acids Res (2006) 34:e115