Stem-loop hsa-mir-376a-2

Accession

MI0003529

Symbol

HGNC: MIR376A2

Description

Homo sapiens hsa-mir-376a-2 precursor miRNA mir-368

Gene
family

RF04291; mir-368

Literature search

79 open access papers mention hsa-mir-376a-2
(405 sentences)

Sequence

1762 reads, 68 reads per million, 67 experiments

gguauuuaaaaGGUAGAUUUUCCUUCUAUGGUuacguguuugaugguuaAUCAUAGAGGAAAAUCCACGUuuucaguauc
((((((.((((.((.(((((((((.((((((((((((.....)))..)))))))))))))))))).)).)))).))))))

Structure

      u    G  A         U         --   g 
gguauu aaaa GU GAUUUUCCU CUAUGGUua  cgu u
|||||| |||| || ||||||||| |||||||||  ||| u
cuauga uuuU CA CUAAAAGGA GAUACUAau  gua u
      c    G  C         -         ug   g 

Annotation confidence High

Comments

The mature miR-376a products have been shown to be modified by A to I edits [2].

Genome context

chr14: 101040069-101040148 [+]

Clustered miRNAs

15 other miRNAs are < 10 kb from hsa-mir-376a-2

Mature hsa-miR-376a-3p

• Accession: MIMAT0000729
• Description: Homo sapiens hsa-miR-376a-3p mature miRNA
• Sequence: 50 - AUCAUAGAGGAAAAUCCACGU - 70
• Evidence: experimental ; cloned [1,3], SOLiD [4]

Mature hsa-miR-376a-2-5p

• Accession: MIMAT0022928
• Description: Homo sapiens hsa-miR-376a-2-5p mature miRNA
• Sequence: 12 - GGUAGAUUUUCCUUCUAUGGU - 32
• Evidence: experimental ; SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


3. PubMed ID: 17322061
   Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
   "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
   "Science (2007) 315:1137-1140


4. PubMed ID: 22282338
   Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
   "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
   "RNA (2012) 18:472-484