Stem-loop hsa-mir-584

Accession

MI0003591

Symbol

HGNC: MIR584

Description

Homo sapiens hsa-mir-584 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR584 is a microRNA that has been found to be upregulated in the liver [PMC4482373]. It is also involved in pancreatic neuroendocrine tumors (pNETs) and pancreatic ductal adenocarcinoma [PMC9554633]. Other miRNAs identified in pNETs include miR1285, miR550a-5P, and miR1825 [PMC9554633]. In the context of H. pylori-induced inflammation and gastric carcinogenesis, let-7b, miR-103, miR-370, and miR-371-5p are downregulated, while miR-21, miR-25, and MIR584 are upregulated [PMC5081003]. MIR584 has been shown to regulate ovarian cancer progression by targeting lipin-1 [PMC8122924]. Low levels of MIR584 are associated with increased metastasis spreading and poor prognosis in ovarian cancer [PMC8122924]. Depletion of MIR584 expression in ovarian cancer cells leads to increased lipin-1 expression and tumorigenesis [PMC8122924].

Literature search

25 open access papers mention hsa-mir-584
(431 sentences)

Sequence

25963 reads, 403 reads per million, 54 experiments

uagggugaccagccaUUAUGGUUUGCCUGGGACUGAGgaauuugcugggauaugUCAGUUCCAGGCCAACCAGGCUgguuggucucccugaagcaac
(((((.(((((((((...(((((.((((((((((((.(.((((....)))).).)))))))))))).)))))...))))))))).))))).......

Structure

-------     u         UUA     U            G a    g 
       uaggg gaccagcca   UGGUU GCCUGGGACUGA g auuu c
       ||||| |||||||||   ||||| |||||||||||| | ||||  
       guccc cugguuggU   ACCAA CGGACCUUGACU u uagg u
caacgaa     u         CGG     C            g a    g 

Annotation confidence High

Genome context

chr5: 149062313-149062409 [-]

Disease association

hsa-mir-584 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-584-5p

• Accession: MIMAT0003249
• Description: Homo sapiens hsa-miR-584-5p mature miRNA
• Sequence: 16 - UUAUGGUUUGCCUGGGACUGAG - 37
• Evidence: experimental ; Microarray [1], RT-PCR [1], SAGE [1], cloned [2-3]

Mature hsa-miR-584-3p

• Accession: MIMAT0022708
• Description: Homo sapiens hsa-miR-584-3p mature miRNA
• Sequence: 55 - UCAGUUCCAGGCCAACCAGGCU - 76
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692