Stem-loop hsa-mir-653

Accession

MI0003674

Symbol

HGNC: MIR653

Description

Homo sapiens hsa-mir-653 precursor miRNA mir-653

Gene
family

RF00937; mir-653

Literature search

8 open access papers mention hsa-mir-653
(9 sentences)

Sequence

730 reads, 6 reads per million, 51 experiments

uucauuccuucaGUGUUGAAACAAUCUCUACUGaaccagcuucaaacaagUUCACUGGAGUUUGUUUCAAUAuugcaagaaugauaagauggaagc
.((((((...((((((((((((((.(((((.(((((.............))))).))))).))))))))))))))...))))))............

Structure

-----------u      cuu              U     C     cagcu 
            ucauuc   caGUGUUGAAACAA CUCUA UGaac     u
            ||||||   |||||||||||||| ||||| |||||     c
            aguaag   guuAUAACUUUGUU GAGGU ACUUg     a
cgaagguagaau      aac              U     C     aacaa 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr7: 93482760-93482855 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-653

Disease association

hsa-mir-653 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-653-5p

• Accession: MIMAT0003328
• Description: Homo sapiens hsa-miR-653-5p mature miRNA
• Sequence: 13 - GUGUUGAAACAAUCUCUACUG - 33
• Evidence: experimental ; SAGE [1], cloned [2], Illumina [3]

Mature hsa-miR-653-3p

• Accession: MIMAT0026625
• Description: Homo sapiens hsa-miR-653-3p mature miRNA
• Sequence: 51 - UUCACUGGAGUUUGUUUCAAUA - 72
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16505370
   The colorectal microRNAome
   "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
   "Proc Natl Acad Sci U S A (2006) 103:3687-3692


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45