Stem-loop ebv-mir-BART7

Accession

MI0003729

Description

Epstein Barr virus ebv-mir-BART7 precursor miRNA

Sequence

uccaguguccugauCCUGGACCUUGACUAUGAAACAauucuaaaaaaaugCAUCAUAGUCCAGUGUCCAGGGacagugcacucgga
((((((((.(((.((((((((((.((((((((..((.((......)).))..)))))))).)).)))))))).))).))))).)))

Structure

   -     c   a        -  U        AA  a  cu 
ucc agugu cug uCCUGGAC CU GACUAUGA  CA uu  a
||| ||||| ||| |||||||| || ||||||||  || ||   
agg ucacg gac GGGACCUG GA CUGAUACU  gu aa  a
   c     u   a        U  C        AC  a  aa 

Annotation confidence Not enough data

Comments

mir-BART7 was discovered independently by two groups. Cai et al mapped the ends of the mature sequence by cloning [1]. Grundhoff et al confirmed that the 3' arm gives rise to a mature miRNA product, but didnot experimentally determine the extents of that product [2]. This sequence is misnamed miR-BART11 in [2].

Genome context

HHV507799: 146425-146510 [+]

Clustered miRNAs

21 other miRNAs are < 10 kb from ebv-mir-BART7

Disease association

ebv-mir-BART7 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BART7-5p

• Accession: MIMAT0004815
• Description: Epstein Barr virus ebv-miR-BART7-5p mature miRNA
• Sequence: 15 - CCUGGACCUUGACUAUGAAACA - 36
• Evidence: experimental ; cloned [3]

Mature ebv-miR-BART7-3p

• Accession: MIMAT0003416
• Description: Epstein Barr virus ebv-miR-BART7-3p mature miRNA
• Sequence: 51 - CAUCAUAGUCCAGUGUCCAGGG - 72
• Evidence: experimental ; cloned [1,3], array [2], Northern [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16557291
   Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
   Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR
   PLoS Pathog (2006) 2:e23


3. PubMed ID: 16540699
   A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
   "Grundhoff A, Sullivan CS, Ganem D"
   "RNA (2006) 12:733-750