Stem-loop hsa-mir-1296

Accession

MI0003780

Symbol

HGNC: MIR1296

Description

Homo sapiens hsa-mir-1296 precursor miRNA mir-1296

Gene
family

RF01921; mir-1296

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1296 is a microRNA implicated in the regulation of myogenic differentiation through the serotonin-mediated signaling pathway [PMC8396502]. It is one of the 13 miRNAs identified by NanoString results to show significant changes in expression levels in relation to pre-shift/post-shift work and psychological mood states [PMC9105576]. In the context of Alzheimer's disease (AD), MIR1296 is notably downregulated in the cortex of patients, suggesting a potential role in the disease's pathogenesis [PMC7564652]. This downregulation has been consistently observed, confirming MIR1296's altered expression in AD [PMC7564652]. Despite its observed dysregulation, no specific pathway or target has been identified for MIR1296, indicating that further research is needed to elucidate its function and mechanism of action within AD [PMC7564652].

Literature search

13 open access papers mention hsa-mir-1296
(259 sentences)

Sequence

9293 reads, 123 reads per million, 124 experiments

accuaccuaacugggUUAGGGCCCUGGCUCCAUCUCCuuuaggaaaaccuucugugggGAGUGGGGCUUCGACCCUAACCcaggugggcugu
.(((((((....(((((((((....(((((((.((((((..((((....))))..)))))))))))))....))))))))))))))))....

Structure

---a       aacu         CCCU       U      ua    a 
    ccuaccu    gggUUAGGG    GGCUCCA CUCCuu  ggaa a
    |||||||    |||||||||    ||||||| ||||||  ||||  
    gggugga    cCCAAUCCC    UCGGGGU GAGggg  ucuu c
uguc       ----         AGCU       -      ug    c 

Annotation confidence High

Genome context

chr10: 63372957-63373048 [-]

Disease association

hsa-mir-1296 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1296-5p

• Accession: MIMAT0005794
• Description: Homo sapiens hsa-miR-1296-5p mature miRNA
• Sequence: 16 - UUAGGGCCCUGGCUCCAUCUCC - 37
• Evidence: experimental ; Illumina [2,4], 454 [3]

Mature hsa-miR-1296-3p

• Accession: MIMAT0026637
• Description: Homo sapiens hsa-miR-1296-3p mature miRNA
• Sequence: 59 - GAGUGGGGCUUCGACCCUAACC - 80
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


2. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621


3. PubMed ID: 19508715
   Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing
   Nygaard S, Jacobsen A, Lindow M, Eriksen J, Balslev E, Flyger H, Tolstrup N, Møller S, Krogh A, Litman T
   BMC Med Genomics (2009) 2:35


4. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45