Stem-loop bta-mir-29a

Accession

MI0004733

Description

Bos taurus bta-mir-29a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

bta-mir-29a, a microRNA, is notably expressed at higher levels in the adult bovine ovarian cortex compared to the fetal ovary, indicating a potential role in ovarian function and development [PMC2762473]. This microRNA was chosen for cellular localization studies due to its differential expression, suggesting its significance in reproductive tissues [PMC2762473]. Additionally, bta-mir-29a is among the miRNAs differentially expressed in bovine milk and plasma during early pregnancy [PMC6418173], and it has been implicated in processes related to pregnancy maintenance and immune function [PMC9445238]. Its stability has led to its proposed use as an internal control for normalizing qPCR data in studies involving bovine milk small extracellular vesicles (sEVs) [PMC9961204]. Network analysis further associates bta-mir-29a with key uterine proteins, indicating a strong interaction with reproductive processes at the molecular level [PMC8273763]. Despite variable expression patterns observed under different conditions, bta-mir-29a's consistent association with reproductive tissues underscores its potential as a biomarker for reproductive status and health in cattle [PMC5662615], while also being inversely correlated with lysosomal activity suggesting an involvement in cellular processes beyond reproduction [PMC9378797].

Literature search

31 open access papers mention bta-mir-29a
(133 sentences)

Sequence

151250 reads, 1228 reads per million, 76 experiments

augacugauuucuuuugguguucagagucaauauaauuuuCUAGCACCAUCUGAAAUCGGUUAu
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))

Structure

            uuu       c    ucaa 
augacugauuuc   ugguguu agag    u
||||||||||||   ||||||| ||||    a
uAUUGGCUAAAG   ACCACGA UCuu    u
            UCU       -    uuaa 

Annotation confidence High

Genome context

chr4: 95726868-95726931 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from bta-mir-29a

Mature bta-miR-29a

• Accession: MIMAT0003518
• Description: Bos taurus bta-miR-29a mature miRNA
• Sequence: 41 - CUAGCACCAUCUGAAAUCGGUUA - 63
• Evidence: experimental ; cloned [1-2]

References

1. PubMed ID: 17105755
   Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues
   "Coutinho LL, Matukumalli LK, Sonstegard TS, Van Tassell CP, Gasbarre LC, Capuco AV, Smith TP"
   "Physiol Genomics (2007) 29:35-43


2. PubMed ID: 17306260
   Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland
   "Gu Z, Eleswarapu S, Jiang H"
   "FEBS Lett (2007) 581:981-988