miRBase entry: xtr-mir-449a

Stem-loop xtr-mir-449a

Accession

MI0004957

Description

Xenopus tropicalis xtr-mir-449a precursor miRNA

Sequence

cuguguuuagaaggaAGGCAGUGUAAUGUUAGCUGGUuggaaaauagcagacacUGGUUAACUUACACCUGCCCCCcuucuuuacau
..((((..((((((..((((((((((.((((((((((((........))...))))))))))))))).)))))..))))))..))))

Structure

cu    uu      aA     -     U          ---  gaa 
  gugu  agaagg  GGCAG UGUAA GUUAGCUGGU   ug   a
  ||||  ||||||  ||||| ||||| ||||||||||   ||    
  uaca  ucuucC  CCGUC ACAUU CAAUUGGUca   ac   a
--    uu      CC     C     -          cag  gau

Annotation confidence Not enough data

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Comments

Expression of the miR-449 family sequences is validated in X. laevis by SOLID sequencing [1].

Genome context

chr1: 178899869-178899955 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from xtr-mir-449a

Name	Accession	Chromosome	Start	End	Strand	Confidence

Database links

Mature xtr-miR-449a-5p

Accession	MIMAT0003704
Description	Xenopus tropicalis xtr-miR-449a-5p mature miRNA
Sequence	16 - AGGCAGUGUAAUGUUAGCUGGU - 37
Evidence	not_experimental

Mature xtr-miR-449a-3p

Accession	MIMAT0022716
Description	Xenopus tropicalis xtr-miR-449a-3p mature miRNA
Sequence	55 - UGGUUAACUUACACCUGCCCCC - 76
Evidence	not_experimental

References

PubMed ID: 21602795
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
"Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P"
"Nat Cell Biol (2011) 13:693-699