Stem-loop ebv-mir-BART18

Accession

MI0004991

Description

Epstein Barr virus ebv-mir-BART18 precursor miRNA

Sequence

uuguugccguugaaagacggguguccuggcUCAAGUUCGCACUUCCUAUACAguguuaaagccuugUAUCGGAAGUUUGGGCUUCGUCccaguguacucgauaaugucgacugcugcga
((((.((.(((((....((((((.(((((..((((((((.((((((.((((((.((....)).)))))).)))))).))))))).)..)))).)))))))......))))).)).))))

Structure

    u  c     --aaga      u -    cU -       C      U      u  u 
uugu gc guuga      cgggug c cugg  C AAGUUCG ACUUCC AUACAg gu a
|||| || |||||      |||||| | ||||  | ||||||| |||||| |||||| ||  
agcg cg cagcu      gcucau g gacc  G UUCGGGU UGAAGG UAUguu cg a
    u  u     guaaua      - u    CU C       U      C      c  a 

Annotation confidence Not enough data

Comments

The arm of the precursor miRNA giving rise to the mature sequence was verified using microarray hybridisation and Northern blot, but the extents of the mature miRNA shown here are predicted and not experimentally determined [1]. This sequence was named miR-BART10 by Grundhoff et al [1] but is not related to ebv-miR-BART10 (MIR:MI0003732). The mature miRNA names and sequences reflect cloning frequencies from Landgraf et al. [2], and may differ subtly from previous annotations.

Genome context

HHV507799: 145932-146050 [+]

Clustered miRNAs

21 other miRNAs are < 10 kb from ebv-mir-BART18

Disease association

ebv-mir-BART18 is associated with one or more human diseases in the Human microRNA Disease Database

Mature ebv-miR-BART18-5p

• Accession: MIMAT0003717
• Description: Epstein Barr virus ebv-miR-BART18-5p mature miRNA
• Sequence: 31 - UCAAGUUCGCACUUCCUAUACA - 52
• Evidence: experimental ; array [1], Northern [1], cloned [2]

Mature ebv-miR-BART18-3p

• Accession: MIMAT0004835
• Description: Epstein Barr virus ebv-miR-BART18-3p mature miRNA
• Sequence: 67 - UAUCGGAAGUUUGGGCUUCGUC - 88
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16540699
   A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses
   "Grundhoff A, Sullivan CS, Ganem D"
   "RNA (2006) 12:733-750