Stem-loop gga-mir-21

Accession

MI0004994

Description

Gallus gallus gga-mir-21 precursor miRNA mir-21

Gene
family

RF00658; mir-21

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Gga-mir-21 is a differentially expressed miRNA in chickens that has been studied in relation to its role in fighting against Infectious Bursal Disease Virus (IBDV) [PMC3700833]. To validate the Illumina small RNA deep sequencing data, five differentially expressed miRNAs, including gga-mir-21, were selected and their expression levels were quantified using real-time quantitative RT-PCR (qRT-PCR) [PMC3700833]. The study found that gga-mir-21 is upregulated in chickens as a defense mechanism against IBDV by inhibiting viral replication [PMC5097849]. This suggests that gga-mir-21 plays a role in the immune response to IBDV infection in chickens. The upregulation of gga-mir-21 may be a protective mechanism to limit viral replication and reduce the severity of the infection. This finding highlights the importance of miRNAs, such as gga-mir-21, in modulating immune responses and fighting against viral infections. Further research is needed to fully understand the mechanisms by which gga-mir-21 functions and its potential as a therapeutic target for IBDV infections [PMC5097849].

Literature search

31 open access papers mention gga-mir-21
(211 sentences)

Sequence

1933092 reads, 34970 reads per million, 5 experiments

uguaccauccugucggaUAGCUUAUCAGACUGAUGUUGAcuguuggaucucauggCAACAACAGUCGGUAGGCUGUCugacauuuugguaucucuca
.((((((...((((((((((((((((.(((((.(((((.((((........))))))))).)))))))))))))))))))))...))))))......

Structure

-----u      ucc                A     A     A    ugg 
      guacca   ugucggaUAGCUUAUC GACUG UGUUG cugu   a
      ||||||   |||||||||||||||| ||||| ||||| ||||    
      uauggu   acaguCUGUCGGAUGG CUGAC ACAAC ggua   u
acucuc      uuu                -     A     -    cuc 

Annotation confidence High

Genome context

chr19: 7376247-7376343 [+]

Mature gga-miR-21-5p

• Accession: MIMAT0003774
• Description: Gallus gallus gga-miR-21-5p mature miRNA
• Sequence: 18 - UAGCUUAUCAGACUGAUGUUGA - 39
• Evidence: experimental ; cloned [1-2], Northern [1], Illumina [3]

Mature gga-miR-21-3p

• Accession: MIMAT0026643
• Description: Gallus gallus gga-miR-21-3p mature miRNA
• Sequence: 56 - CAACAACAGUCGGUAGGCUGUC - 77
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 18256158
   MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
   "Yao Y, Zhao Y, Xu H, Smith LP, Lawrie CH, Watson M, Nair V"
   "J Virol (2008) 82:4007-4015


2. PubMed ID: 16750530
   Identification of microRNAs from different tissues of chicken embryo and adult chicken
   "Xu H, Wang X, Du Z, Li N"
   "FEBS Lett (2006) 580:3610-3616


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45