Stem-loop hsa-mir-934

Accession

MI0005756

Symbol

HGNC: MIR934

Description

Homo sapiens hsa-mir-934 precursor miRNA mir-934

Gene
family

RF01025; mir-934

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR934 is a microRNA whose single nucleotide polymorphism (SNP) at position n.15T>G in the 1st nucleotide in the 5p strand affects the cleavage sites of DROSHA/DICER1, leading to the production of a novel isomiR [PMC9708458]. This alteration was validated through luciferase assays, which confirmed the interaction between MIR934 and its target genes TFCP2L1 and RAB3B [PMC7295570]. In silico analysis and luciferase assays further identified MIR934 binding sites on the 3'-UTR of FZD5, TFCP2L1, and RAB3B, with varying degrees of conservation across species [PMC7295570]. Specifically, MIR934 was shown to bind at certain sites on these mRNAs in HEK293T cells [PMC7295570]. Additionally, research on colorectal cancer (CRC) cells demonstrated that knockdown of miR-934 affects cell proliferation and cell cycle by transfecting cells with a MIR934 inhibitor [PMC8809948]. The expression levels of circRNF10 and MIR934 were quantified using specific primers to further understand their relationship in CRC [PMC9739140].

Literature search

5 open access papers mention hsa-mir-934
(8 sentences)

Sequence

292 reads, 2 reads per million, 40 experiments

agaaauaaggcuucUGUCUACUACUGGAGACACUGGuaguauaaaacccagagucuccaguaauggacgggagccuuauuucu
((((((((((((((((((((.((((((((((.((((...........)))).)))))))))).))))))))))))))))))))

Structure

                    C          A    uagu 
agaaauaaggcuucUGUCUA UACUGGAGAC CUGG    a
|||||||||||||||||||| |||||||||| ||||    u
ucuuuauuccgagggcaggu augaccucug gacc    a
                    a          a    caaa 

Annotation confidence Not enough data

Genome context

chrX: 136550878-136550960 [+]

Disease association

hsa-mir-934 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-934

• Accession: MIMAT0004977
• Description: Homo sapiens hsa-miR-934 mature miRNA
• Sequence: 15 - UGUCUACUACUGGAGACACUGG - 36
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043