Stem-loop hsa-mir-944

Accession

MI0005769

Symbol

HGNC: MIR944

Description

Homo sapiens hsa-mir-944 precursor miRNA mir-944

Gene
family

RF01024; mir-944

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR944 is a microRNA that has been identified as overexpressed in patients with non-small cell lung cancer (NSCLC) relative to healthy controls, with a more than fourfold increase in expression [PMC5627048]. It has been implicated in modulating sensitivity to chemotherapy in solid tumors [PMC8602334]. The MIR944 promoter is transcriptionally regulated by ΔNp63, particularly during keratinocyte differentiation, with ΔNp63 binding to the promoter maintained during this process [PMC4551945]. Co-regulators such as TFAP2A and TFAP2C have been identified as supporting the binding of ΔNp63 to the MIR944 promoter, suggesting a complex regulatory mechanism that maintains miR-944 expression during epidermal differentiation [PMC4551945]. The chromatin architecture of the MIR944 genomic region is open in keratinocytes, facilitating transcription initiation [PMC4551945]. Conservation analyses indicate that MIR944 is evolutionarily young and primate-specific, suggesting its recent emergence and potential specialized function in these species [PMC4551945]. Overall, MIR944 appears to be an important regulatory miRNA with its own promoter within the intron of ΔNp63 and may play a role in epidermal differentiation and cancer biology [PMC4551945][PMC6510770[PMC6510770].

Literature search

12 open access papers mention hsa-mir-944
(94 sentences)

Sequence

4462 reads, 101 reads per million, 61 experiments

guuccagacacaucucaucugauauacaauauuuucuuaaauuguauaaagagAAAUUAUUGUACAUCGGAUGAGcugugucugggau
((((((((((((.((((((((((.(((((((.((((((............)))))).))))))).)))))))))).))))))))))))

Structure

            u          a       u      aaauu 
guuccagacaca cucaucugau uacaaua uuucuu     g
|||||||||||| |||||||||| ||||||| ||||||      
uagggucugugu GAGUAGGCUA AUGUUAU AAAgag     u
            c          C       U      aaaua 

Annotation confidence Low

Genome context

chr3: 189829922-189830009 [+]

Disease association

hsa-mir-944 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-944

• Accession: MIMAT0004987
• Description: Homo sapiens hsa-miR-944 mature miRNA
• Sequence: 54 - AAAUUAUUGUACAUCGGAUGAG - 75
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043