Stem-loop hsa-mir-944

Accession

MI0005769

Symbol

HGNC: MIR944

Description

Homo sapiens hsa-mir-944 precursor miRNA mir-944

Gene
family

RF01024; mir-944

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR944 is a microRNA that has been studied in various contexts. It has been found to be overexpressed in patients with non-small cell lung cancer (NSCLC) [PMC5627048]. MIR944 has also been shown to modulate sensitivity to chemotherapy in other solid tumors [PMC8602334]. The MIR944 promoter is regulated by the transcription factor ΔNp63, which binds to the promoter region and activates transcription [PMC4551945]. The binding of ΔNp63 to the MIR944 promoter is reinforced by the co-regulator AP-2 [PMC4551945]. The chromatin structure of the MIR944 promoter region is relatively open in keratinocytes, which allows for transcription initiation [PMC4551945]. Conservation analyses have shown that MIR944 is a relatively young gene in evolutionary terms, with conservation limited to primates [PMC4551945'>PMC4551945]. TFAP2A and TFAP2C have been identified as co-regulators that bind to the MIR944 promoter and enhance ΔNp63-mediated activation of transcription [PMC4551945]. The activity of the MIR944 promoter is dependent on ΔNp63 expression, but not linearly dependent on its quantity [PMC4551945]. Overall, these findings suggest that MIR944 has its own independent promoter and its expression is regulated by ΔNp63 and co-regulators such as AP-2, TFAP2A, and TFAP2C.

Literature search

12 open access papers mention hsa-mir-944
(94 sentences)

Sequence

4463 reads, 309 reads per million, 62 experiments

guuccagacacaucucaucugauauacaauauuuucuuaaauuguauaaagagAAAUUAUUGUACAUCGGAUGAGcugugucugggau
((((((((((((.((((((((((.(((((((.((((((............)))))).))))))).)))))))))).))))))))))))

Structure

            u          a       u      aaauu 
guuccagacaca cucaucugau uacaaua uuucuu     g
|||||||||||| |||||||||| ||||||| ||||||      
uagggucugugu GAGUAGGCUA AUGUUAU AAAgag     u
            c          C       U      aaaua 

Annotation confidence Not enough data

Genome context

chr3: 189829922-189830009 [+]

Disease association

hsa-mir-944 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-944

• Accession: MIMAT0004987
• Description: Homo sapiens hsa-miR-944 mature miRNA
• Sequence: 54 - AAAUUAUUGUACAUCGGAUGAG - 75
• Evidence: experimental ; cloned [1]

References

1. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043