Stem-loop hiv1-mir-N367

Accession

MI0006104

Description

Human immunodeficiency virus 1 hiv1-mir-N367 precursor miRNA

Sequence

uuggcagaauuacacaccagggccagggaucagauauccACUGACCUUUGGAUGGUGCUUCAAgcuagua
(((((.(((.(((.((((((((.(((((((.....)))).))).)).)))).))))).)))..)))))..

Structure

--     -a   u   a  -    -  c   -    c 
  uuggc  gaa uac ca ccag gg cag ggau a
  |||||  ||| ||| || |||| || ||| |||| g
  gaucg  CUU GUG GU GGUU CC GUC ccua a
au     AA   C   -  A    U  A   A    u 

Annotation confidence Not enough data

Comments

Extensive studies in two labs have failed to confirm the existence of any viral miRNAs in HIV [3,4]. This sequence should be considered at risk of deletion from future releases of miRBase.

Genome context

Unknown

Mature hiv1-miR-N367

• Accession: MIMAT0004478
• Description: Human immunodeficiency virus 1 hiv1-miR-N367 mature miRNA
• Sequence: 40 - ACUGACCUUUGGAUGGUGCUUCAA - 63
• Evidence: experimental ; cloned [2], Northern [2]

References

1. PubMed ID: 15782219
   Identification of microRNAs of the herpesvirus family
   "Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T"
   "Nat Methods (2005) 2:269-276


2. PubMed ID: 15601474
   HIV-1 nef suppression by virally encoded microRNA
   Omoto S, Ito M, Tsutsumi Y, Ichikawa Y, Okuyama H, Brisibe EA, Saksena NK, Fujii YR
   Retrovirology (2004) 1:44


3. PubMed ID: 15722536
   Regulation of human immunodeficiency virus 1 transcription by nef microRNA
   "Omoto S, Fujii YR"
   "J Gen Virol (2005) 86:751-755


4. PubMed ID: 17855543
   Analysis of the interaction of primate retroviruses with the human RNA interference machinery
   "Lin J, Cullen BR"
   "J Virol (2007) 81:12218-12226