Stem-loop hsa-mir-1293

Accession

MI0006355

Symbol

HGNC: MIR1293

Description

Homo sapiens hsa-mir-1293 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1293 is a microRNA implicated in the pathogenesis of lung adenocarcinoma (LUAD), with its high expression associated with poor survival outcomes in patients [PMC7212445]. It is one of the four genes identified as prognostic biomarkers in LUAD, suggesting its significant role in the disease's progression [PMC7212445]. Despite its emerging importance, as of the last search, there were no public reports specifically focusing on MIR1293 and its role in LUAD [PMC7212445]. MIR1293's expression level is higher in the high-risk group compared to the low-risk group, indicating its potential utility as a biomarker for risk stratification [PMC7212445]. Additionally, MIR1293 has been identified to regulate viral and human interleukin-6 through binding sites on their open reading frames (ORF), indicating a broader regulatory role beyond LUAD [PMC9495386]. Furthermore, expression patterns of MIR1293 have been observed to be deregulated similarly to other microRNAs in leukoplakia and leukoplakia-transformed cancer tissues, suggesting a potential role in other cancerous transformations as well [PMC5011738].

Literature search

6 open access papers mention hsa-mir-1293
(9 sentences)

Sequence

178 reads, 164 reads per million, 38 experiments

agguuguucUGGGUGGUCUGGAGAUUUGUGCagcuuguaccugcacaaaucuccggaccacuuagucuuua
........(((((((((((((((((((((((((.......)))))))))))))))))))))))))......

Structure

agguuguu                         cu 
        cUGGGUGGUCUGGAGAUUUGUGCag  u
        |||||||||||||||||||||||||  g
        gauucaccaggccucuaaacacguc  u
--auuucu                         ca 

Annotation confidence Not enough data

Genome context

chr12: 50234142-50234212 [-]

Disease association

hsa-mir-1293 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1293

• Accession: MIMAT0005883
• Description: Homo sapiens hsa-miR-1293 mature miRNA
• Sequence: 10 - UGGGUGGUCUGGAGAUUUGUGC - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621