Stem-loop hsa-mir-1293

Accession

MI0006355

Symbol

HGNC: MIR1293

Description

Homo sapiens hsa-mir-1293 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1293 is a microRNA that has been studied in the context of lung adenocarcinoma (LUAD). Univariate Cox regression analysis has shown that high expression of MIR1293 is associated with poor survival outcomes in LUAD [PMC7212445]. In contrast, high expression of LINC01740, another gene in the ceRNA network, is associated with good survival outcomes [PMC7212445]. In a combined step regression and Cox regression analysis, MIR1293 was identified as one of four genes that serve as prognostic biomarkers in LUAD [PMC7212445]. Furthermore, MIR1293 was found to be a novel important prognostic factor involved in LUAD pathogenesis [PMC7212445]. In a study comparing expression levels between high-risk and low-risk groups, it was observed that the expression level of MIR1293 was higher in the high-risk group [PMC7212445]. Additionally, MIR1293 has been shown to be involved in the regulation of vIL-6 and hIL-6 through binding sites in their open reading frames (ORF) [PMC9495386]. Expression deregulation patterns of several miRNAs, including MIR1293, have been observed in leukoplakia and leukoplakia-transformed cancer tissues [PMC5011738]. References: - [PMC7212445]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212445/ - [PMC9495386]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495386/ - [PMC5011738]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011738/

Literature search

6 open access papers mention hsa-mir-1293
(9 sentences)

Sequence

178 reads, 164 reads per million, 38 experiments

agguuguucUGGGUGGUCUGGAGAUUUGUGCagcuuguaccugcacaaaucuccggaccacuuagucuuua
........(((((((((((((((((((((((((.......)))))))))))))))))))))))))......

Structure

agguuguu                         cu 
        cUGGGUGGUCUGGAGAUUUGUGCag  u
        |||||||||||||||||||||||||  g
        gauucaccaggccucuaaacacguc  u
--auuucu                         ca 

Annotation confidence Not enough data

Genome context

chr12: 50234142-50234212 [-]

Disease association

hsa-mir-1293 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1293

• Accession: MIMAT0005883
• Description: Homo sapiens hsa-miR-1293 mature miRNA
• Sequence: 10 - UGGGUGGUCUGGAGAUUUGUGC - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621