Accession
MI0006372
Symbol
HGNC:
MIR1305
Description
Homo sapiens
hsa-mir-1305 precursor miRNA mir-1305
Gene
family?
family?
RF04109;
mir-1305
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1305 is a microRNA that has been implicated in various biological processes and diseases. In a study, it was found that overexpression of circCOG2, a circular RNA, led to pro-EMT (epithelial-mesenchymal transition) and activation of TGF-β2. However, this effect was rescued by miR-1305 overexpression, which resulted in the upregulation of E-cadherin and downregulation of vimentin, TGF-β2, SMAD3, and p-SMAD3 [PMC8505430]. In ovarian cancer patients with a shallow deletion of MIR1305 and high DIRAS3 expression (a tumor suppressor gene), better overall survival was observed compared to patients with no alteration in MIR1305 copy number variation [PMC9101105]. MIR1305 has also been implicated in the regulation of osteogenic differentiation [PMC8503254]. Furthermore, it was found that MIR1305 expression is induced by atRA exposure [PMC4168020]. However, there is currently no report linking MIR1305 to RIF (recurrent implantation failure) or its association with upstream circRNA [PMC7924221]. Additionally, the inhibition of NUCKS1 affects changes in the expression of several microRNAs including miR4796, MIR1305, miR4762, and miR4445 [PMC5830027]. These findings highlight the diverse roles and potential clinical relevance of MIR1305 in various biological processes and diseases.
Literature search
7 open access papers mention hsa-mir-1305
(63 sentences)
(63 sentences)
Sequence
356
reads,
32
reads per million, 40 experiments
aagauccugcuguuucuaccauuaguuuugaauguuuauuguaaagauacUUUUCAACUCUAAUGGGAGAGAcagcaggauucucc
..(((((((((((((((.(((((((..(((((....((((.....))))...)))))..))))))).)))))))))))))))....
..(((((((((((((((.(((((((..(((((....((((.....))))...)))))..))))))).)))))))))))))))....
Structure
--aa a uu uguu g
gauccugcuguuucu ccauuag uugaa uauu u
||||||||||||||| ||||||| ||||| |||| a
uuaggacgacAGAGA GGUAAUC AACUU auag a
ccuc G UC -UUc a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr4: 182169293-182169378 [+]
Disease association
hsa-mir-1305 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1305
| Accession | MIMAT0005893 |
| Description | Homo sapiens hsa-miR-1305 mature miRNA |
| Sequence | 51 - UUUUCAACUCUAAUGGGAGAGA - 72 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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