Dead hairpin entry

Stem-loop hsa-mir-1248

Accession

MI0006383

Symbol

HGNC: MIR1248

Description

Homo sapiens hsa-mir-1248 precursor miRNA

Comment

The read data does not support this entry being a bona fide miRNA.

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

WARNING: This summary was generated by AI. MIR1248 is a microRNA that exhibits a very high expression level in stallion sperm, with an expression count (AC) of 100 or greater, indicating its significant presence in these cells [PMC3569414]. It is known to target 154 genes and shows upregulation in certain human cell lines, such as SK-N-SH and K562 [PMC5600530]. Interestingly, MIR1248 may selectively target specific isoforms of OGG1 due to variations in the mRNA 3′UTR regions [PMC9118907]. In the context of drug resistance, MIR1248 is slightly up-regulated with moderate absolute expression levels in TamR cells [PMC3402532]. It has also been implicated in the regulation of genes associated with aging, as its regulation has been confirmed in old hematopoietic stem cells (HSC) compared to young HSC [PMC8296523]. Furthermore, MIR1248's expression levels are inversely correlated with PSMD10 expression levels [PMC9414407], and it is one of the top microRNAs that are upregulated following IFN-γ stimulation [PMC8010072]. This microRNA also shows differential regulation under conditions such as inflammation and drug resistance.

Literature search

42 open access papers mention hsa-mir-1248
(107 sentences)

Sequence

14397 reads, 45.0 reads per million, 114 experiments

uuuACCUUCUUGUAUAAGCACUGUGCUAAAauugcagacacuaggaccaugucuugguuuuugcaauaaugcuagcagaguacacaCAAGAAGAAAAGUAACAGCa
.....((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).............

Structure

--------uuuAC        AUAA C   G     ---AA        c        c 
             CUUCUUGU    G ACU UGCUA     auugcaga acuaggac  
             ||||||||    | ||| |||||     |||||||| |||||||| a
             GAAGAACa    c uga acgau     uaacguuu ugguucug  
aCGACAAUGAAAA        --ca a   g     cguaa        u        u