Accession
MI0006384
Symbol
HGNC:
MIR1249
Description
Homo sapiens
hsa-mir-1249 precursor miRNA mir-1249
Gene
family?
family?
RF01918;
mir-1249
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1249 is a microRNA that has been identified as one of the top up-regulated genes in certain cellular contexts [PMC9279949]. It has been implicated in the regulation of chemo-resistance, particularly through its role in the expansion of CD133+ cancer stem cells (CSCs) [PMC7590111]. Inhibition of MIR1249 has been shown to increase chemo-sensitivity by limiting the expansion of resistant cell populations, suggesting its potential as a therapeutic target [PMC7590111]. MIR1249 is also associated with Wnt signaling pathways, with pathway analysis indicating an enrichment in Wnt signaling upon MIR1249 upregulation [PMC7590111]. Clinically, high tumor expression of MIR1249 correlates with a worse prognosis independently of adjuvant chemotherapy [PMC7590111'>PMC7590111]. Furthermore, pathway analysis revealed that inhibition of MIR1249 affects pathways deregulated by chemotherapy, indicating its role in mediating chemo-resistance through these pathways [PMC7590111]. In vivo studies have confirmed that knockout (KO) cells for MIR1249 exhibit reduced tumorigenicity and increased sensitivity to chemotherapy, reinforcing its significance in cancer progression and treatment resistance [PMC7590111].
Literature search
16 open access papers mention hsa-mir-1249
(33 sentences)
(33 sentences)
Sequence
2157
reads,
67
reads per million, 118 experiments
gggAGGAGGGAGGAGAUGGGCCAAGUUcccucuggcuggaACGCCCUUCCCCCCCUUCUUCAccug
.(((((((((.((.((.((((...(((((........))))))))).)).))))))))))).....
.(((((((((.((.((.((((...(((((........))))))))).)).))))))))))).....
Structure
----g A A U CAA cuc
ggAGGAGGG GG GA GGGC GUUcc u
||||||||| || || |||| |||||
CUUCUUCCC CC CU CCCG CAagg g
guccA - C U --- ucg
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr22: 45200954-45201019 [-]
Disease association
hsa-mir-1249 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1249-3p
| Accession | MIMAT0005901 |
| Description | Homo sapiens hsa-miR-1249-3p mature miRNA |
| Sequence | 41 - ACGCCCUUCCCCCCCUUCUUCA - 62 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-1249-5p
| Accession | MIMAT0032029 |
| Description | Homo sapiens hsa-miR-1249-5p mature miRNA |
| Sequence | 4 - AGGAGGGAGGAGAUGGGCCAAGUU - 27 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
|
