Stem-loop hsa-mir-1258

Accession

MI0006392

Symbol

HGNC: MIR1258

Description

Homo sapiens hsa-mir-1258 precursor miRNA mir-1258

Gene
family

RF03863; mir-1258

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-1258 is a cellular miRNA that inhibits the reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency and downregulates the expression of heparanase (HPSE) protein levels, which restricts breast cancer brain metastasis invasion [PMC7252873]. It is negatively correlated with several transmembrane emp24 domain-containing proteins (TMEDs) and is considered a tumor suppressor in breast cancer [PMC9816852]. Hsa-mir-1258 is upregulated in the skin of patients with postherpetic neuralgia (PHN) [PMC8914318]. It has also been found to be downregulated in gastric cancer and breast cancer, where it targets HPSE and reactivation transcriptional activator (RTA), respectively [PMC4350105] [PMC7354774]. Hsa-mir-1258 has been identified as one of the top upregulated differentially expressed miRNAs in ischemic stroke samples [PMC3565366]. It is also altered in metastatic cancers, including gastric cancer and acute myocardial infarction, where it may serve as a diagnostic biomarker [PMC4491873] [PMC9061009] [PMC8923688]. Overall, hsa-mir-1258 plays a role in inhibiting viral reactivation, regulating tumor metastasis, and may have diagnostic potential for certain diseases.

Literature search

5 open access papers mention hsa-mir-1258
(15 sentences)

Sequence

772 reads, 32 reads per million, 37 experiments

cuguggcuuccacgaccuaauccuaacuccugcgagucccuggAGUUAGGAUUAGGUCGUGGAAgccacagga
((((((((((((((((((((((((((((((...........))))))))))))))))))))))))))))))..

Structure

--                              ugcg 
  cuguggcuuccacgaccuaauccuaacucc    a
  ||||||||||||||||||||||||||||||    g
  gacaccgAAGGUGCUGGAUUAGGAUUGAgg    u
ag                              uccc 

Annotation confidence Not enough data

Genome context

chr2: 179860836-179860908 [-]

Disease association

hsa-mir-1258 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1258

• Accession: MIMAT0005909
• Description: Homo sapiens hsa-miR-1258 mature miRNA
• Sequence: 44 - AGUUAGGAUUAGGUCGUGGAA - 64
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621