Stem-loop hsa-mir-1258

Accession

MI0006392

Symbol

HGNC: MIR1258

Description

Homo sapiens hsa-mir-1258 precursor miRNA mir-1258

Gene
family

RF03863; mir-1258

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

hsa-mir-1258 is a cellular microRNA that has been implicated in the regulation of viral infection and cancer progression. It has been observed to inhibit the reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency, suggesting a role in controlling viral infections [PMC7252873]. Additionally, hsa-mir-1258 downregulates heparanase (HPSE) protein levels, which is associated with restricted bone marrow-derived breast cancer (BMBC) cell invasion [PMC7252873]. This microRNA is also involved in the regulation of tumor microenvironment and metastasis, as it has been identified as a tumor suppressor in breast cancer [PMC9816852]. In the context of KSHV infection, hsa-mir-1258 expression is reduced, which may facilitate an increase in HPSE expression and promote cell survival signaling for the benefit of the virus [PMC7252873]. Moreover, hsa-mir-1258's role extends to other diseases as it was found to be upregulated in postherpetic neuralgia patients' skin [PMC8914318] and involved in gastric cancer progression [PMC6815795]. It also targets RTA 3'UTR leading to reduced KSHV reactivation [PMC4926176] and has been identified as part of a miRNA-based diagnostic prediction model for diseases like bronchopulmonary dysplasia (BPD) [PMC9061009].

Literature search

5 open access papers mention hsa-mir-1258
(15 sentences)

Sequence

772 reads, 32 reads per million, 37 experiments

cuguggcuuccacgaccuaauccuaacuccugcgagucccuggAGUUAGGAUUAGGUCGUGGAAgccacagga
((((((((((((((((((((((((((((((...........))))))))))))))))))))))))))))))..

Structure

--                              ugcg 
  cuguggcuuccacgaccuaauccuaacucc    a
  ||||||||||||||||||||||||||||||    g
  gacaccgAAGGUGCUGGAUUAGGAUUGAgg    u
ag                              uccc 

Annotation confidence Not enough data

Genome context

chr2: 179860836-179860908 [-]

Disease association

hsa-mir-1258 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1258

• Accession: MIMAT0005909
• Description: Homo sapiens hsa-miR-1258 mature miRNA
• Sequence: 44 - AGUUAGGAUUAGGUCGUGGAA - 64
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621