Stem-loop hsa-mir-1260a

Accession

MI0006394

Symbol

HGNC: MIR1260A

Description

Homo sapiens hsa-mir-1260a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1260A is a microRNA that has been found to be significant in certain contexts. In a study, it was observed that MIR1260A and mir93.3p became significant when women with male factor infertility were omitted, suggesting that these microRNAs may be markers of pre-existing pathologies [PMC9580729]. Further analysis of MIR1260A's gene targets revealed that it had 42 common gene targets when compared with gene target lists from miRTarBase and TargetScan [PMC8504092]. These common gene targets were found to have significant interactions at the protein level [PMC8504092]. Additionally, the study suggested that MIR1260A and miR1260b, which were found to be differentiated in peripheral blood, could serve as prognostic bioindicators [PMC8504092]. The higher expression level of MIR1260A and miR-1260b was also reported in the serum and FFPE tissues of prostate cancer patients [PMC8504092]. In patients who received no chemotherapy, the expression level of MIR1260A was found to have both increased and decreased [PMC8504092]. Furthermore, in a different study, it was observed that on day 7, both MIR1260A and miR1260b were downregulated compared to baseline samples in certain groups [PMC7169272]. Overall, these findings highlight the significance of MIR1260A in various contexts.

Literature search

23 open access papers mention hsa-mir-1260a
(58 sentences)

Sequence

529 reads, 892 reads per million, 28 experiments

accuuuccagcucAUCCCACCUCUGCCACCAaaacacucaucgcggggucagagggagugccaaaaaagguaa
((((((...((.(.((((...((((((.((..............)))).))))))))).))....))))))..

Structure

--      -cca  u A    ACC    -  A  Aaaaca 
  accuuu    gc c UCCC   UCUG CC CC      c
  ||||||    || | ||||   |||| || ||       
  uggaaa    cg g aggg   agac gg gg      u
aa      aaac  u -    ---    u  -  cgcuac 

Annotation confidence Not enough data

Genome context

chr14: 77266218-77266290 [+]

Disease association

hsa-mir-1260a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1260a

• Accession: MIMAT0005911
• Description: Homo sapiens hsa-miR-1260a mature miRNA
• Sequence: 14 - AUCCCACCUCUGCCACCA - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621