Stem-loop hsa-mir-1260a

Accession

MI0006394

Symbol

HGNC: MIR1260A

Description

Homo sapiens hsa-mir-1260a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1260A, a microRNA, has been identified as a significant biomarker in the context of female infertility, as its significance emerged when cases of male infertility were excluded from the study [PMC9580729]. This suggests that MIR1260A may be associated with female reproductive pathologies or could serve as an indicator of such conditions [PMC9580729]. Further research has narrowed down the gene targets of MIR1260A to 42 significant genes through a comparison between TargetScan and miRTarBase databases [PMC8504092]. These gene targets have been shown to interact significantly at the protein level according to String database analysis [PMC8504092]. Additionally, MIR1260A has been proposed as a potential prognostic biomarker due to its differential expression in peripheral blood [PMC8504092]. Its expression levels have also been observed in serum and FFPE tissues of prostate cancer patients, indicating its potential relevance in oncology [PMC8504092]. Interestingly, while MIR1260A expression levels varied among patients with prostate cancer who did not receive chemotherapy—increasing in 50% and decreasing in another 50%—it was consistently downregulated on day 7 compared to baseline levels on day 1 across different control and irradiated groups [PMC8504092; PMC7169272]..

Literature search

23 open access papers mention hsa-mir-1260a
(58 sentences)

Sequence

529 reads, 892 reads per million, 28 experiments

accuuuccagcucAUCCCACCUCUGCCACCAaaacacucaucgcggggucagagggagugccaaaaaagguaa
((((((...((.(.((((...((((((.((..............)))).))))))))).))....))))))..

Structure

--      -cca  u A    ACC    -  A  Aaaaca 
  accuuu    gc c UCCC   UCUG CC CC      c
  ||||||    || | ||||   |||| || ||       
  uggaaa    cg g aggg   agac gg gg      u
aa      aaac  u -    ---    u  -  cgcuac 

Annotation confidence Not enough data

Genome context

chr14: 77266218-77266290 [+]

Disease association

hsa-mir-1260a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1260a

• Accession: MIMAT0005911
• Description: Homo sapiens hsa-miR-1260a mature miRNA
• Sequence: 14 - AUCCCACCUCUGCCACCA - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621