Stem-loop hsa-mir-548n

Accession

MI0006399

Symbol

HGNC: MIR548N

Description

Homo sapiens hsa-mir-548n precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR548N is a microRNA that has been found to exhibit vulnerability to mutation in certain regions of the genome [PMC6756205]. Somatic deletions of approximately 500 bp in chromosome 2, specifically in the PRKRA and MIR548N genes, have been detected in samples from patients with schizophrenia [PMC6756205]. In a study investigating genetic variants associated with uncertain significance, one variant was found to affect the region harboring MIR548N [PMC6375196]. MIR548N is part of a specific grouping of microRNAs that have not previously been associated with preterm birth, and there is limited information about their function in disease processes [PMC5429750]. In terms of genetic expression, there have been higher levels of miR548a, miR548aa, miR548ai, miR548ak, and MIR548N observed in term pregnancies compared to preterm births [PMC5429750]. The region containing MIR548N has also been associated with a variant within the PRKRA gene and a noncoding transcript [PMC4289690]. Additionally, MIR548N has been identified as one of several brain-enriched microRNA-coding long noncoding RNAs [PMC4468152]. The somatic deletion affecting PRKRA and MIR548N was found only in DNA from the prefrontal cortex and not in DNA from other tissues [PMC3897957].

Literature search

47 open access papers mention hsa-mir-548n
(158 sentences)

Sequence

683 reads, 108 reads per million, 72 experiments

agguuggugCAAAAGUAAUUGUGGAUUUUGUcguuaaaaauagcaaaacccgcaauuacuuuugcaccaaccuaa
((((((((((((((((((((((((.((((((.(((...))).)))))).))))))))))))))))))))))))..

Structure

--                        A      c   a 
  agguuggugCAAAAGUAAUUGUGG UUUUGU guu  
  |||||||||||||||||||||||| |||||| ||| a
  uccaaccacguuuucauuaacgcc aaaacg uaa  
aa                        c      a   a 

Annotation confidence Not enough data

Genome context

chr7: 34940760-34940834 [-]

Disease association

hsa-mir-548n is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-548n

• Accession: MIMAT0005916
• Description: Homo sapiens hsa-miR-548n mature miRNA
• Sequence: 10 - CAAAAGUAAUUGUGGAUUUUGU - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621