Stem-loop hsa-mir-548n

Accession

MI0006399

Symbol

HGNC: MIR548N

Description

Homo sapiens hsa-mir-548n precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR548N is a member of the microRNA 548 family, which has not been extensively studied in the context of disease processes, including its association with preterm birth or placental function [PMC5429750]. This microRNA, along with others in its family such as miR548a, miR548aa, miR548ai, and miR548ak, has been identified as brain-enriched and is a part of a group that includes precursors for various other microRNAs [PMC4468152]. Notably, MIR548N is located on chromosome 2 and has been found to be susceptible to somatic deletions of approximately 500 base pairs in patients with schizophrenia [PMC6756205]. These deletions also affect the PRKRA gene and have been observed specifically in DNA from the prefrontal cortex but not from cerebellum or blood [PMC3897957]. Additionally, MIR548N is situated within exon 6 of PRKRA and near a noncoding transcript at a genomic location associated with significant variant effects [PMC4289690]. The vulnerability of this region to mutation suggests that MIR548N may have an as-yet-undetermined role in neuropsychiatric conditions or other biological processes.

Literature search

47 open access papers mention hsa-mir-548n
(158 sentences)

Sequence

683 reads, 108 reads per million, 72 experiments

agguuggugCAAAAGUAAUUGUGGAUUUUGUcguuaaaaauagcaaaacccgcaauuacuuuugcaccaaccuaa
((((((((((((((((((((((((.((((((.(((...))).)))))).))))))))))))))))))))))))..

Structure

--                        A      c   a 
  agguuggugCAAAAGUAAUUGUGG UUUUGU guu  
  |||||||||||||||||||||||| |||||| ||| a
  uccaaccacguuuucauuaacgcc aaaacg uaa  
aa                        c      a   a 

Annotation confidence Not enough data

Genome context

chr7: 34940760-34940834 [-]

Disease association

hsa-mir-548n is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-548n

• Accession: MIMAT0005916
• Description: Homo sapiens hsa-miR-548n mature miRNA
• Sequence: 10 - CAAAAGUAAUUGUGGAUUUUGU - 31
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621