Stem-loop hsa-mir-1275

Accession

MI0006415

Symbol

HGNC: MIR1275

Description

Homo sapiens hsa-mir-1275 precursor miRNA mir-1275

Gene
family

RF02022; mir-1275

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1275 is identified as a functional microRNA coding gene with implications in various diseases and physiological processes [PMC6871504]. It has been associated with coronary atherosclerosis and is one of the microRNAs that have been downregulated in certain conditions [PMC7123062][PMC7989380[PMC7989380]. Specifically, MIR1275 has been implicated in the pathogenesis of multiple sclerosis and is targeted by the probe cg03903398, indicating its significance in gene regulation [PMC6871504]. In the context of type 1 diabetes (T1D), MIR1275 is among a set of 11 miRNAs that have potential as biomarkers due to their roles in immune regulation, beta cell function, and insulin processing [PMC7731293][PMC6768498[PMC6768498]. Furthermore, MIR1275's expression has been negatively correlated with genes associated with mitochondrial membrane potential suppression induced by multi-walled carbon nanotubes (MWCNTs) [PMC8327461]. It also appears to be dysregulated in certain cancers and infections, suggesting its broader impact on cell proliferation and immune responses [PMC5865775]. In cancer research, MIR1275 has been shown to be involved in tumor invasion and metastasis by targeting genes such as LGALS1 through interactions with proteins like RACK1 modified by O-GlcNAcylation [PMC10006576]. Additionally, circular RNAs like circFNDC3B have been hypothesized to sequester MIR1275, affecting its regulatory functions on mRNA targets [PMC7361139].

Literature search

33 open access papers mention hsa-mir-1275
(58 sentences)

Sequence

6111 reads, 359 reads per million, 147 experiments

ccucugugagaaaggguGUGGGGGAGAGGCUGUCuugugucuguaaguaugccaaacuuauuuuccccaaggcagaggga
(((((((...........((((((((((((...((((......))))...))).......)))))))))..)))))))..

Structure

--       gagaaaggguG         -------   UGU    ug 
  ccucugu           UGGGGGAGA       GGC   Cuug  u
  |||||||           |||||||||       |||   ||||   
  ggagacg           accccuuuu       ccg   gaau  c
ag       ---------ga         auucaaa   uau    gu 

Annotation confidence Not enough data

Genome context

chr6: 33999972-34000051 [-]

Disease association

hsa-mir-1275 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1275

• Accession: MIMAT0005929
• Description: Homo sapiens hsa-miR-1275 mature miRNA
• Sequence: 18 - GUGGGGGAGAGGCUGUC - 34
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621