Accession
MI0006416
Symbol
HGNC:
MIR1276
Description
Homo sapiens
hsa-mir-1276 precursor miRNA mir-1276
Gene
family?
family?
RF03453;
mir-1276
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1276 is a direct target gene of NF-κB in HeLa and HepG2 cells, and its expression is repressed by NF-κB [PMC7177739]. NF-κB upregulates the expression of CASP9 by directly binding to CASP9, but represses the expressions of MIR1276 and its host gene KLHL25 [PMC7177739]. CASP9 is a true target gene of MIR1276 [PMC7177739]. The level of snRNA U6 expression is used for the normalization of MIR1276 expression [PMC7177739'>PMC7177739'>PMC7177739'>PMC7177739]. TargetScan and DIANA-microT-CDS programs were used to predict the binding of MIR1276 to CASP9 mRNA, and it was confirmed that MIR1276 specifically binds to the 3′UTR of CASP9 [PMC7177739]. The expressions of MIR1276 and its host gene KLHL25 are similar in various cell types [PMC7177739]. NF-κB indirectly enhances CASP9 expression by directly repressing the expression of MIR1276 [PMC7177739]. The regulation between NF-κB, MIR1276, and CASP9 forms a coherent feed-forward loop (FFL) that upregulates the mRNA and protein levels of CASP9 in TNFα-treated cells [PMC7177739].
Sequence
768
reads,
29
reads per million, 51 experiments
ccccagcuaggUAAAGAGCCCUGUGGAGACAccuggauucagagaacaugucuccacugagcacuugggccuugauggcggcu
(((((...((((.(((.((.(.(((((((((((((....))).)....))))))))).).)).)))..))))...))).))..
(((((...((((.(((.((.(.(((((((((((((....))).)....))))))))).).)).)))..))))...))).))..
Structure
-- - gcu -A A C U ---- - g cc cca aggU AAG GC C GUGGAGACA c cug a || ||| |||| ||| || | ||||||||| | ||| gg ggu uccg uuc cg g caccucugu g gac u uc c agu gg a a u acaa a u
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr15: 85770496-85770578 [-]
Disease association
hsa-mir-1276 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1276
| Accession | MIMAT0005930 |
| Description | Homo sapiens hsa-miR-1276 mature miRNA |
| Sequence | 12 - UAAAGAGCCCUGUGGAGACA - 31 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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