MIR1908 is a micro-RNA encoded by the MIR1908 gene located on chromosome 11 and is implicated in various biological processes and diseases [PMC9469614]. It has been identified as a potential biomarker for prostate cancer, with lower expression in tumor tissues compared to normal tissues, suggesting a role as a proliferation suppressor [PMC5696163]. MIR1908 has been associated with the activation of the AKT pathway in neuronal models, although this relationship was not observed in HuH-7 liver cancer cells [PMC8660805]. Additionally, MIR1908 expression appears to be regulated independently of the FADS1/2 loci despite their genomic proximity [PMC8660805]. The gene has also been linked to bipolar disorder (BD), with significant associations found after correction for multiple testing [PMC9547016]. Functional analyses have suggested that certain genetic variants within MIR1908 may alter its secondary structure and potentially its function [PMC9547016]. Despite these associations, further research is needed to fully understand the biological mechanisms and clinical significance of MIR1908.
---- aau C A A Cc g cggg gccg GGCGGGG CGGCG UUGGU guau u |||| |||| ||||||| ||||| ||||| |||| g gccc cgGC CCGCCUC GCCGC GGCCa cgug u cccc --c C G C -c g
Disease | Description | Category | PubMed ID |
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Accession | MIMAT0007881 |
Description | Homo sapiens hsa-miR-1908-5p mature miRNA |
Sequence | 12 - CGGCGGGGACGGCGAUUGGUC - 32 |
Evidence |
experimental
454 [1-2], Illumina [3] |
Database links |
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Predicted targets |
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Accession | MIMAT0026916 |
Description | Homo sapiens hsa-miR-1908-3p mature miRNA |
Sequence | 49 - CCGGCCGCCGGCUCCGCCCCG - 69 |
Evidence |
experimental
Illumina [4] |
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