Accession
MI0008329
Symbol
HGNC:
MIR1908
Description
Homo sapiens
hsa-mir-1908 precursor miRNA mir-1908
Gene
family?
family?
RF03314;
mir-1908
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1908 is a microRNA encoded by the MIR1908 gene on the minus strand of chromosome 11 [PMC9469614]. Previous studies have shown that MIR1908 is associated with poor prognosis in ovarian cancer, as its target gene SIRT2 is linked to poor prognosis [PMC8320514]. It has been suggested that MIR1908-3p, rather than MIR1908-5p, may drive AKT activation [PMC8660805]. AMPK activity has been shown to contribute to the maintenance of MIR1908 expression [PMC8660805]. The activation status of AKT in response to MIR1908 targeting has been examined, as the PI3K/AKT/mTOR axis is frequently activated in cancer cells [PMC8660805]. The production of MIR1908-5p may require ongoing glycolysis [PMC8660805'>PMC8660805'>PMC8660805]. However, in neuronal models, overexpression of MIR1908 was shown to activate AKT [PMC8660805]. The expression of FADS1 and FADS2, which are related to MIR1908, was found to be largely insensitive to glucose concentration [PMC8660805]. The regulation of the MIR1908 and FADS1/2 loci appears to be independent based on prior evidence [PMC8660805]. MIR1908 has also been investigated in prostate cancer. It was found that MIR1908 showed a lower expression mode in tumor tissues compared to normal tissues and may serve as a potential biomarker for prostate cancer patients along with other genes such as SPOCK3 and SPON1 [PMC5696163]. Furthermore, studies have examined the association between genetic variants in miRNA coding genes and bipolar disorder (BD). It was found that variants in miRNA coding genes such as MIR499A, MIR708, and especially MIR1908, were significantly associated with BD [PMC9547016]. Functional analyses were performed to determine the impact of these variants on the secondary structure of the respective miRNAs [PMC9547016].
Literature search
19 open access papers mention hsa-mir-1908
(146 sentences)
(146 sentences)
Sequence
495
reads,
79
reads per million, 72 experiments
cgggaaugccgCGGCGGGGACGGCGAUUGGUCcguauguguggugccaCCGGCCGCCGGCUCCGCCCCGgcccccgcccc
((((...((((.(((((((.(((((.(((((..((((.....)))).))))).))))).))))))).)))).))))....
((((...((((.(((((((.(((((.(((((..((((.....)))).))))).))))).))))))).)))).))))....
Structure
---- aau C A A Cc g
cggg gccg GGCGGGG CGGCG UUGGU guau u
|||| |||| ||||||| ||||| ||||| |||| g
gccc cgGC CCGCCUC GCCGC GGCCa cgug u
cccc --c C G C -c g
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr11: 61815161-61815240 [-]
Disease association
hsa-mir-1908 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1908-5p
| Accession | MIMAT0007881 |
| Description | Homo sapiens hsa-miR-1908-5p mature miRNA |
| Sequence | 12 - CGGCGGGGACGGCGAUUGGUC - 32 |
| Evidence |
experimental
454 [1-2], Illumina [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-1908-3p
| Accession | MIMAT0026916 |
| Description | Homo sapiens hsa-miR-1908-3p mature miRNA |
| Sequence | 49 - CCGGCCGCCGGCUCCGCCCCG - 69 |
| Evidence |
experimental
Illumina [4] |
References
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