miRBase entry: hsa-mir-1908

Stem-loop hsa-mir-1908

Homo sapiens hsa-mir-1908 precursor miRNA
Gene family
MIPF0001021; mir-1908

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1908 is a microRNA encoded by the MIR1908 gene on the minus strand of chromosome 11 [PMC9469614]. Previous studies have shown that MIR1908 is associated with poor prognosis in ovarian cancer, as its target gene SIRT2 is linked to poor prognosis [PMC8320514]. It has been suggested that MIR1908-3p, rather than MIR1908-5p, may drive AKT activation [PMC8660805]. AMPK activity has been shown to contribute to the maintenance of MIR1908 expression [PMC8660805]. The activation status of AKT in response to MIR1908 targeting has been examined, as the PI3K/AKT/mTOR axis is frequently activated in cancer cells [PMC8660805]. The production of MIR1908-5p may require ongoing glycolysis [PMC8660805'>PMC8660805'>PMC8660805]. However, in neuronal models, overexpression of MIR1908 was shown to activate AKT [PMC8660805]. The expression of FADS1 and FADS2, which are related to MIR1908, was found to be largely insensitive to glucose concentration [PMC8660805]. The regulation of the MIR1908 and FADS1/2 loci appears to be independent based on prior evidence [PMC8660805].

MIR1908 has also been investigated in prostate cancer. It was found that MIR1908 showed a lower expression mode in tumor tissues compared to normal tissues and may serve as a potential biomarker for prostate cancer patients along with other genes such as SPOCK3 and SPON1 [PMC5696163].

Furthermore, studies have examined the association between genetic variants in miRNA coding genes and bipolar disorder (BD). It was found that variants in miRNA coding genes such as MIR499A, MIR708, and especially MIR1908, were significantly associated with BD [PMC9547016]. Functional analyses were performed to determine the impact of these variants on the secondary structure of the respective miRNAs [PMC9547016].

Literature search
19 open access papers mention hsa-mir-1908
(146 sentences)


495 reads, 79 reads per million, 72 experiments

----    aau    C       A     A     Cc    g 
    cggg   gccg GGCGGGG CGGCG UUGGU  guau u
    ||||   |||| ||||||| ||||| |||||  |||| g
    gccc   cgGC CCGCCUC GCCGC GGCCa  cgug u
cccc    --c    C       G     C     -c    g 

Annotation confidence Not enough data
Do you think this miRNA is real?

Genome context
chr11: 61815161-61815240 [-]

Disease association
hsa-mir-1908 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-1908-5p

Accession MIMAT0007881
Description Homo sapiens hsa-miR-1908-5p mature miRNA
Evidence experimental
454 [1-2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-1908-3p

Accession MIMAT0026916
Description Homo sapiens hsa-miR-1908-3p mature miRNA
Evidence experimental
Illumina [4]


  1. PubMed ID: 19508715
    Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing
    Nygaard S, Jacobsen A, Lindow M, Eriksen J, Balslev E, Flyger H, Tolstrup N, Møller S, Krogh A, Litman T
    BMC Med Genomics (2009) 2:35

  2. PubMed ID: 18583537
    MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries
    "Bar M, Wyman SK, Fritz BR, Qi J, Garg KS, Parkin RK, Kroh EM, Bendoraite A, Mitchell PS, Nelson AM, Ruzzo WL, Ware C, Radich JP, Gentleman R, Ruohola-Baker H, Tewari M"
    "Stem Cells (2008) 26:2496-2505

  3. PubMed ID: 20224791
    Discovery of novel microRNAs in female reproductive tract using next generation sequencing
    Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PH
    PLoS One (2010) 5:e9637

  4. PubMed ID: 23226537
    The repertoire and features of human platelet microRNAs
    Plé H, Landry P, Benham A, Coarfa C, Gunaratne PH, Provost P
    PLoS One (2012) 7:e50746