Stem-loop hsv1-mir-H4

Accession

MI0008939

Description

Herpes Simplex Virus 1 hsv1-mir-H4 precursor miRNA

Sequence

gccgggguGGUAGAGUUUGACAGGCAAGCAugugcgugcagaggcgaguagugCUUGCCUGUCUAACUCGCUAGUcucggc
(((((((((((.(((((.(((((((((((((.(((.(((....))).)))))))))))))))).))))))))).)))))))

Structure

       -    A     U             g   g   a 
gccgggg uGGU GAGUU GACAGGCAAGCAu ugc ugc g
||||||| |||| ||||| ||||||||||||| ||| |||  
cggcucU AUCG CUCAA CUGUCCGUUCgug aug gcg a
       G    -     U             -   a   g 

Annotation confidence Not enough data

Comments

The mature sequence from the 5' arm of this hairpin was named miR-LAT-ICP34.5 in [2].

Genome context

Unknown

Mature hsv1-miR-H4-5p

• Accession: MIMAT0008401
• Description: Herpes Simplex Virus 1 hsv1-miR-H4-5p mature miRNA
• Sequence: 9 - GGUAGAGUUUGACAGGCAAGCA - 30
• Evidence: experimental ; 454 [1], qRT-PCR [1], Illumina [3-4]

Mature hsv1-miR-H4-3p

• Accession: MIMAT0008402
• Description: Herpes Simplex Virus 1 hsv1-miR-H4-3p mature miRNA
• Sequence: 54 - CUUGCCUGUCUAACUCGCUAGU - 75
• Evidence: experimental ; 454 [1], qRT-PCR [1], cloned [2], Illumina [3]

References

1. PubMed ID: 20181707
   Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2
   "Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM"
   "J Virol (2010) 84:4659-4672


2. PubMed ID: 18596690
   MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs
   "Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR"
   "Nature (2008) 454:780-783


3. PubMed ID: 19656888
   Analysis of human alphaherpesvirus microRNA expression in latently infected human trigeminal ganglia
   "Umbach JL, Nagel MA, Cohrs RJ, Gilden DH, Cullen BR"
   "J Virol (2009) 83:10677-10683


4. PubMed ID: 18678906
   An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor
   "Tang S, Bertke AS, Patel A, Wang K, Cohen JI, Krause PR"
   "Proc Natl Acad Sci U S A (2008) 105:10931-10936