Accession
MI0014130
Symbol
HGNC:
MIR3117
Description
Homo sapiens
hsa-mir-3117 precursor miRNA mir-3117
Gene
family?
family?
RF03591;
mir-3117
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR3117 is a microRNA (miRNA) that has been identified as a hub gene with prognostic significance in certain cancers and is associated with patient prognosis [PMC9660063]. It is regulated by HNRNPC and contributes to a risk score model for patient outcomes [PMC9660063]. MIR3117 has been observed to have lower expression levels in certain cereal crops such as rice, maize, and sorghum [PMC6358896]. It plays a role in post-transcriptional regulation of PHLPP2 across various cancers, including breast, colon, ovarian, and liver cancer [PMC8078721]. The rapid expansion of MIR3117 in the Triticum subgenome A suggests its quick evolutionary changes over short timescales [PMC6651130]'>PMC6651130], and it is conserved within the Ehrhartoideae and Pooideae subfamilies [PMC6651130]. In Triticum species (wheat), MIR3117 targets NB-LRR transcripts to trigger the production of phased small interfering RNAs (phasiRNAs) [PMC7057497], which are involved in plant defense mechanisms. A significant association has been found between the MIR3117 rs7512692 C>T polymorphism and tumor grade in cancer patients [PMC8184203]. Additionally, single nucleotide polymorphisms (SNPs) within MIR3117 have been linked to an increased risk of B-cell acute lymphoblastic leukemia (B-ALL), potentially affecting the MAPK signaling pathway [PMC7167988], highlighting its role in disease susceptibility.
Literature search
1 open access papers mention hsa-mir-3117
(1 sentences)
(1 sentences)
Sequence
605
reads,
8
reads per million, 43 experiments
cccuaaagggccAGACACUAUACGAGUCAUAUaagggaaggcauuAUAGGACUCAUAUAGUGCCAGguguuuuguggg
((((((((.(((.(.(((((((.(((((.(((((.(.....).))))).))))).))))))).).))).))))).)))
((((((((.(((.(.(((((((.(((((.(((((.(.....).))))).))))).))))))).).))).))))).)))
Structure
- g A A C A g g ccc uaaag gcc G CACUAUA GAGUC UAUaa g a ||| ||||| ||| | ||||||| ||||| ||||| | a ggg guuuu ugG C GUGAUAU CUCAG AUAuu c g u g A C A G a g
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr1: 66628440-66628517 [+]
Disease association
hsa-mir-3117 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-3117-3p
| Accession | MIMAT0014979 |
| Description | Homo sapiens hsa-miR-3117-3p mature miRNA |
| Sequence | 46 - AUAGGACUCAUAUAGUGCCAG - 66 |
| Evidence |
experimental
Illumina [1-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-3117-5p
| Accession | MIMAT0019197 |
| Description | Homo sapiens hsa-miR-3117-5p mature miRNA |
| Sequence | 13 - AGACACUAUACGAGUCAUAU - 32 |
| Evidence |
experimental
Illumina [2-3] |
References
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