miRBase entry: hsa-mir-1260b

Stem-loop hsa-mir-1260b


Accession
MI0014197
Symbol
HGNC: MIR1260B
Description
Homo sapiens hsa-mir-1260b precursor miRNA mir-1260b
Gene
family?
RF04175; mir-1260b

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1260B is a microRNA implicated in various cellular processes and has been identified as a potential biomarker in cancer research [PMC8504092]. Analysis has revealed that miR-1260b is closely associated with the Serine/Threonine-protein kinase family, including CHEK2 and CDK4, which are important in cell cycle regulation [PMC8504092]. It has been suggested that miR-1260b, along with miR1260a, shows differential expression in the peripheral blood of ovarian cancer patients compared to healthy controls, indicating potential prognostic and diagnostic significance [PMC8504092]. Furthermore, common gene targets of MIR1260B have been identified to interact at the protein level [PMC8504092]. In prostate cancer (PCa), MIR1260B expression can be modulated by genistein, which affects cell proliferation by altering both oncogenic and oncosuppressor microRNAs [PMC7072821]. Additionally, MIR1260B interacts with various protein-coding genes and non-coding RNAs including HNRNPK, suggesting a complex regulatory network influenced by this microRNA [PMC9730017]. Inhibition of MIR1260B has been shown to affect cell proliferation in colorectal cancer cells when combined with chemotherapeutic agents like 5-FU [PMC6144919], while genistein-mediated down-regulation of MIR1260B can decrease PCa cell proliferation through epigenetic modifications [PMC5068501].

Literature search
34 open access papers mention hsa-mir-1260b
(73 sentences)

Sequence

3936 reads, 91 reads per million, 95 experiments
ucuccguuuAUCCCACCACUGCCACCAUuauugcuacuguucagcaggugcugcugguggugauggugauagucuggugggggcggugg
.(.((((...(((((((((((.((((((((((((.......((((((...)))))))))))))))))).))))..))))))))))).).

Structure
u u    uuA       --    C            uacuguu      g 
 c ccgu   UCCCACC  ACUG CACCAUuauugc       cagcag  
 | ||||   |||||||  |||| ||||||||||||       |||||| u
 g ggcg   ggggugg  ugau gugguaguggug       gucguc  
g u    ---       uc    a            -------      g 


Annotation confidence Not enough data
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Genome context
chr11: 96341438-96341526 [+]

Disease association
hsa-mir-1260b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1260b

Accession MIMAT0015041
Description Homo sapiens hsa-miR-1260b mature miRNA
Sequence 10 - AUCCCACCACUGCCACCAU - 28
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 20300190
    Characterization of the Melanoma miRNAome by Deep Sequencing
    "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
    "PLoS One (2010) 5:e9685