Stem-loop hsa-mir-1260b

Accession

MI0014197

Symbol

HGNC: MIR1260B

Description

Homo sapiens hsa-mir-1260b precursor miRNA mir-1260b

Gene
family

RF04175; mir-1260b

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1260B is a microRNA molecule that has been found to have a close association with the Serin/Treonin-protein kinase family member of CHEK2 protein and cycline dependent kinase family members of CDK4 protein [PMC8504092]. It has been suggested that the expression of MIR1260B in peripheral blood lymphocytes may have prognostic significance and could be used as a bioindicator [PMC8504092]. The gene targets of MIR1260B, as detected from miRTarBase and TargetScan, have been found to interact at the protein level according to analysis performed using the String database [PMC8504092]. The significant expression of MIR1260B in peripheral blood lymphocytes has been demonstrated in ovarian cancer patients compared to healthy controls, suggesting its potential diagnostic significance in ovarian cancer [PMC8504092]. In a study using qPCR, TaqMan primers were used to analyze the expression of MIR1260B [PMC6144919]. It has also been shown that MIR1260B is involved in regulating SFRP1 expression in prostate cancer [PMC8869457]. Genistein treatment has been found to modulate the levels of various miRNAs, including MIR1260B, and affect cancer cell proliferation in prostate cancer [PMC7072821]. Furthermore, HNRNPK interacts with several genes including MIR1260B at the protein level [PMC9730017]. The abundance of MIR1260B in A-exosomes suggests its potential role in targeting specific mRNA and genes with functional consequences [PMC8176431]. In addition, miR1260a and MIR1260B were downregulated on day 7 compared to baseline samples on day 1 [PMC7169272]. Other miRNA genes located on 11q include MIR3166, miR3167, and MIR1260B, but their functions are unknown [PMC5492892]. Genistein treatment has been found to down-regulate MIR1260B expression in prostate cancer cells [PMC5068501].

Literature search

34 open access papers mention hsa-mir-1260b
(73 sentences)

Sequence

3936 reads, 91 reads per million, 95 experiments

ucuccguuuAUCCCACCACUGCCACCAUuauugcuacuguucagcaggugcugcugguggugauggugauagucuggugggggcggugg
.(.((((...(((((((((((.((((((((((((.......((((((...)))))))))))))))))).))))..))))))))))).).

Structure

u u    uuA       --    C            uacuguu      g 
 c ccgu   UCCCACC  ACUG CACCAUuauugc       cagcag  
 | ||||   |||||||  |||| ||||||||||||       |||||| u
 g ggcg   ggggugg  ugau gugguaguggug       gucguc  
g u    ---       uc    a            -------      g 

Annotation confidence Not enough data

Genome context

chr11: 96341438-96341526 [+]

Disease association

hsa-mir-1260b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1260b

• Accession: MIMAT0015041
• Description: Homo sapiens hsa-miR-1260b mature miRNA
• Sequence: 10 - AUCCCACCACUGCCACCAU - 28
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20300190
   Characterization of the Melanoma miRNAome by Deep Sequencing
   "Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, Parsons PG, Schmidt C, Sturm RA, Hayward NK"
   "PLoS One (2010) 5:e9685