Accession
MI0014197
Symbol
HGNC:
MIR1260B
Description
Homo sapiens
hsa-mir-1260b precursor miRNA mir-1260b
Gene
family?
family?
RF04175;
mir-1260b
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1260B is a microRNA implicated in various cellular processes and has been identified as a potential biomarker in cancer research [PMC8504092]. Analysis has revealed that miR-1260b is closely associated with the Serine/Threonine-protein kinase family, including CHEK2 and CDK4, which are important in cell cycle regulation [PMC8504092]. It has been suggested that miR-1260b, along with miR1260a, shows differential expression in the peripheral blood of ovarian cancer patients compared to healthy controls, indicating potential prognostic and diagnostic significance [PMC8504092]. Furthermore, common gene targets of MIR1260B have been identified to interact at the protein level [PMC8504092]. In prostate cancer (PCa), MIR1260B expression can be modulated by genistein, which affects cell proliferation by altering both oncogenic and oncosuppressor microRNAs [PMC7072821]. Additionally, MIR1260B interacts with various protein-coding genes and non-coding RNAs including HNRNPK, suggesting a complex regulatory network influenced by this microRNA [PMC9730017]. Inhibition of MIR1260B has been shown to affect cell proliferation in colorectal cancer cells when combined with chemotherapeutic agents like 5-FU [PMC6144919], while genistein-mediated down-regulation of MIR1260B can decrease PCa cell proliferation through epigenetic modifications [PMC5068501].
Literature search
34 open access papers mention hsa-mir-1260b
(73 sentences)
(73 sentences)
Sequence
3936
reads,
91
reads per million, 95 experiments
ucuccguuuAUCCCACCACUGCCACCAUuauugcuacuguucagcaggugcugcugguggugauggugauagucuggugggggcggugg
.(.((((...(((((((((((.((((((((((((.......((((((...)))))))))))))))))).))))..))))))))))).).
.(.((((...(((((((((((.((((((((((((.......((((((...)))))))))))))))))).))))..))))))))))).).
Structure
u u uuA -- C uacuguu g c ccgu UCCCACC ACUG CACCAUuauugc cagcag | |||| ||||||| |||| |||||||||||| |||||| u g ggcg ggggugg ugau gugguaguggug gucguc g u --- uc a ------- g
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr11: 96341438-96341526 [+]
Disease association
hsa-mir-1260b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1260b
| Accession | MIMAT0015041 |
| Description | Homo sapiens hsa-miR-1260b mature miRNA |
| Sequence | 10 - AUCCCACCACUGCCACCAU - 28 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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