MIR3065 is a nonprotein coding regulatory gene implicated in breast cancer (BC) development, particularly among African American women, as suggested by a study by Perrson et al. [PMC5989404]. This microRNA is transcribed in the opposite direction from its host gene, apoptosis-associated tyrosine kinase (AATK), within the seventh intron of BAIAP2 [PMC5989404]. It has been identified in regions of genomic amplification across various BC subtypes and exhibits a notably different expression pattern between normal and breast tumor tissues [PMC5989404]. The expression of MIR3065 is highest in breast tumors compared to other tissues, with lung and placenta showing the next highest levels [PMC5989404'>PMC5989404'>PMC5989404]. Single nucleotide polymorphisms (SNPs) within the BAIAP2 intron and pri-MIR3065 sequence may affect MIR3065 biogenesis and BAIAP2 expression, potentially influencing BC risk [PMC5989404]. Functional studies are needed to elucidate the molecular mechanisms behind MIR3065's association with BC risk, especially estrogen receptor-positive BC [PMC5989404]. Moreover, MIR3065 may play a role in suppressing oncogenes as it targets genes like ARID4B and RAB22A involved in cancer development [PMC5989404].
c A A A ------ g g cug ccucuUCAACAA AUC CUG UGCUG GA uc c ||| |||||||||||| ||| ||| ||||| || || gac ggaGAGGUUGUU UAG GAC ACGAC cu ag c a A - C Ucacua g u
Name | Accession | Chromosome | Start | End | Strand | Confidence |
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Disease | Description | Category | PubMed ID |
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Accession | MIMAT0015066 |
Description | Homo sapiens hsa-miR-3065-5p mature miRNA |
Sequence | 10 - UCAACAAAAUCACUGAUGCUGGA - 32 |
Evidence |
experimental
Illumina [1,3], 454 [2] |
Database links |
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Predicted targets |
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Accession | MIMAT0015378 |
Description | Homo sapiens hsa-miR-3065-3p mature miRNA |
Sequence | 50 - UCAGCACCAGGAUAUUGUUGGAG - 72 |
Evidence |
experimental
Illumina [1,3], 454 [2] |
Database links |
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Predicted targets |
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