Accession
MI0016422
Symbol
HGNC:
MIR3916
Description
Homo sapiens
hsa-mir-3916 precursor miRNA
Comment
The read data does not support this entry being a bona fide miRNA.
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
WARNING: This summary was generated by AI. MIR3916 is a microRNA that has been identified as positively correlated with certain genes in the context of diabetic kidney disease (DKD), although specific reports on its role in DKD are lacking [PMC8325821]. It is differentially expressed in patients with mismatch repair (MMR) deficiency, with higher expression levels observed in MMR+ patients [PMC6036478]. MIR3916 has been implicated in the destabilization of desmosomes, which are cellular structures involved in cell adhesion, suggesting a potential role in aging-related cellular processes [PMC8282276]. Furthermore, MIR3916 is associated with the regulation of calcium handling genes, which are crucial for cardiac function and have been reported to be impaired with aging [PMC8282276]. Notably, MIR3916 appears to have a significant regulatory impact on cardiac genes, potentially influencing 63% of these genes across various functional categories [PMC8282276]. It also targets several cardiac-specific proteins such as TNNC1 and TNNT2, indicating its involvement in the regulation of heart muscle proteins [PMC8282276].
Literature search
5 open access papers mention hsa-mir-3916
(5 sentences)
(5 sentences)
Sequence
2071
reads,
71.0
reads per million, 96 experiments
aucccagagaagaaggAAGAAGAGGAAGAAAUGGCUGguucucaggugaaugugucuggguucaggggauguguCUCCUCUUUUCUUCUGGGAU
((((((((......((((((.(((((.((.....((((..((((((........)))))).))))........)))))))))))))))))))))
((((((((......((((((.(((((.((.....((((..((((((........)))))).))))........)))))))))))))))))))))
Structure
gaagaa A A ---AAUGG uu uga
aucccaga ggAAGA GAGGA GA CUGg cucagg a
|||||||| |||||| ||||| || |||| ||||||
UAGGGUCU UCUUUU CUCCU Cu gacu gggucu u
------ - - guguaggg -u gug
