Accession
MI0016768
Symbol
HGNC:
MIR4429
Description
Homo sapiens
hsa-mir-4429 precursor miRNA mir-4429
Gene
family?
family?
RF03507;
mir-4429
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4429 is a microRNA that has been found to be associated with tumor growth suppression and is detected in malignant struma ovarii [PMC10047136]. It has been suggested that MIR4429 targets METTL3 and prevents the m6A modification of SEC62 mRNA, leading to the destabilization of SEC62 mRNA [PMC7272606]. In patients with stroke, MIR4429 levels are lower in peripheral blood mononuclear cells, while in non-small cell lung cancer (NSCLC) patients, MIR4429 levels are significantly lower compared to healthy controls [PMC7123062] [PMC9392976]. NSCLC patients with low MIR4429 levels have been found to have poor overall survival [PMC9392976'>PMC9392976]. The expression levels of MIR4429 in circulation may be influenced by the VAS/SAT ratio and activity in adipose tissue [PMC6240145]. In genome-wide analyses, MIR4429 has been associated with endometriosis and various types of ovarian cancer (HGSOC, CCOC) [PMC9040176]. Additionally, it has been shown that MIR4429 inhibits gastric cancer progression by targeting METTL3 and hindering m6A-induced stabilization of SEC62 mRNA [PMC6920212]. References: - PMC10047136 - PMC7272606 - PMC7123062 - PMC9392976 - PMC6240145 - PMC9040176 - PMC6920212
Literature search
2 open access papers mention hsa-mir-4429
(2 sentences)
(2 sentences)
Sequence
362
reads,
25
reads per million, 58 experiments
agggagAAAAGCUGGGCUGAGAGGCGacuggugucuaauuuguuugucucuccaacucagacugccuggccca
.(((.....(((((((..((((((((((.(((.....))).).)))))))))...))))).))......))).
.(((.....(((((((..((((((((((.(((.....))).).)))))))))...))))).))......))).
Structure
a -agAAA - -CU - u g ggg AG CUGGG GAGAGGCGa c ggu u ||| || ||||| ||||||||| | ||| c ccc uc gacuc cucucuguu g uua u a gguccg a aac u u a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr2: 11540605-11540677 [-]
Disease association
hsa-mir-4429 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4429
| Accession | MIMAT0018944 |
| Description | Homo sapiens hsa-miR-4429 mature miRNA |
| Sequence | 7 - AAAAGCUGGGCUGAGAGGCG - 26 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
|
References
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