Accession
MI0016768
Symbol
HGNC:
MIR4429
Description
Homo sapiens
hsa-mir-4429 precursor miRNA mir-4429
Gene
family?
family?
RF03507;
mir-4429
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4429 is a microRNA implicated in various biological processes related to cancer. DNA methylation analysis has identified MIR4429 as one of the genes methylated in malignant struma ovarii, suggesting a role in tumor growth suppression [PMC10047136]. MIR4429 has been shown to target METTL3, which is involved in the m6A modification of SEC62 mRNA, leading to the destabilization of SEC62 mRNA and potentially inhibiting gastric cancer progression [PMC7272606], [PMC6920212]. In the context of non-small cell lung cancer (NSCLC), patients with lower levels of MIR4429 have been associated with poor overall survival, indicating its potential as a prognostic biomarker [PMC9392976]. Additionally, serum levels of MIR4429 have demonstrated diagnostic potential in distinguishing between patients with different EGFR mutation statuses [PMC9392976]. In stroke patients, altered levels of MIR4429 have been observed in peripheral blood mononuclear cells, suggesting its involvement beyond oncological disorders [PMC7123062]. Furthermore, genome-wide association studies have linked MIR4429 to endometriosis and high-grade serous ovarian cancer (HGSOC), indicating its relevance across various gynecological conditions [PMC9040176].
Literature search
2 open access papers mention hsa-mir-4429
(2 sentences)
(2 sentences)
Sequence
362
reads,
25
reads per million, 58 experiments
agggagAAAAGCUGGGCUGAGAGGCGacuggugucuaauuuguuugucucuccaacucagacugccuggccca
.(((.....(((((((..((((((((((.(((.....))).).)))))))))...))))).))......))).
.(((.....(((((((..((((((((((.(((.....))).).)))))))))...))))).))......))).
Structure
a -agAAA - -CU - u g ggg AG CUGGG GAGAGGCGa c ggu u ||| || ||||| ||||||||| | ||| c ccc uc gacuc cucucuguu g uua u a gguccg a aac u u a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr2: 11540605-11540677 [-]
Disease association
hsa-mir-4429 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4429
| Accession | MIMAT0018944 |
| Description | Homo sapiens hsa-miR-4429 mature miRNA |
| Sequence | 7 - AAAAGCUGGGCUGAGAGGCG - 26 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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