Stem-loop hsa-mir-4451

Accession

MI0016797

Symbol

HGNC: MIR4451

Description

Homo sapiens hsa-mir-4451 precursor miRNA mir-4451

Gene
family

RF03429; mir-4451

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4451 is a microRNA (miRNA) that exhibits dynamic expression patterns in response to various cellular conditions and developmental stages in plants. It was found to be suppressed by atRA exposure, indicating a potential regulatory role in response to this retinoic acid [PMC4168020]. However, during differentiation, MIR4451 was induced alongside other miRNAs, suggesting a complex role in cellular processes [PMC4168020]. In the context of seed development, MIR4451 was one of the miRNAs selected for expression level analysis by qRT-PCR due to its up-regulated expression and its association with nutrient metabolism [PMC6138641]. Interestingly, its expression levels decreased over time from 28 days after flowering (DAF) to 42 DAF in seed grain filling periods (SGP), which could be linked to its role in modulating nutrient storage through its target CM 17 [PMC6138641]. Furthermore, MIR4451's expression was significantly up-regulated from 7 DAF to 21 DAF with a peak at 21 DAF during SGP [PMC6138641]. The target genes of MIR4451 and other miRNAs showed converse expression profiles during grain filling periods, which could indicate regulatory interactions between these miRNAs and their targets during seed development [PMC6138641].

Sequence

153 reads, 13 reads per million, 26 experiments

ucuguaccucagcuuugcucccaaccaaccacuuccacauguuuugcUGGUAGAGCUGAGGACAgc
.((((.(((((((((((((..(((..(((...........))))))..))))))))))))))))).

Structure

u    a             cc   cc   cacu 
 cugu ccucagcuuugcu  caa  aac    u
 |||| |||||||||||||  |||  |||    c
 gACA GGAGUCGAGAUGG  guu  uug    c
c    -             Uc   --   uaca 

Annotation confidence Not enough data

Genome context

chr4: 85722468-85722533 [+]

Disease association

hsa-mir-4451 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4451

• Accession: MIMAT0018973
• Description: Homo sapiens hsa-miR-4451 mature miRNA
• Sequence: 48 - UGGUAGAGCUGAGGACA - 64
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127