Stem-loop hsa-mir-4492

Accession

MI0016854

Symbol

HGNC: MIR4492

Description

Homo sapiens hsa-mir-4492 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4492 is a microRNA gene whose effects and functions are not fully characterized, particularly in the context of multiple sclerosis (MS) and Epstein-Barr Virus (EBV) infection [PMC10061723]'>PMC10061723]], [PMC5492892]. Its expression levels were analyzed by RT-qPCR as part of a panel of microRNAs, but the effects of MIR4492 could not be determined using summary statistics alone [PMC7000740], [PMC10061723]. A risk single nucleotide polymorphism (SNP) has been identified in an enhancer-like domain near MIR4492, suggesting a regulatory mechanism that could influence the expression of this microRNA gene [PMC10061723]. Further research is needed to clarify the impact of this enhancer SNP on MIR4492 expression, especially in MS patients with EBV infection, to understand its potential role in disease pathology [PMC10061723]. MIR4492 is among several miRNA genes located on chromosome 11q, including miR5579 and miR3166, whose functions are also not well understood [PMC5492892]. The specific miRNA situated near 11q23 close to MIR4492 has not been identified in the provided context, and its function remains to be elucidated [PMC5492892].

Literature search

7 open access papers mention hsa-mir-4492
(20 sentences)

Sequence

271 reads, 31 reads per million, 41 experiments

cugcagcgugcuucuccaggccccgcgcgcggacagacacacggacaagucccgccaGGGGCUGGGCGCGCGCCagccgg
..((.((((((...(((((.((((..(((.((((..............)))))))..))))))))).))))))..))...

Structure

-cu  -a      uuc     g    gc   c    agacac 
   gc  gcgugc   uccag cccc  gcg ggac      a
   ||  ||||||   ||||| ||||  ||| ||||       
   cg  CGCGCG   GGGUC GGGG  cgc ccug      c
ggc  aC      --C     -    ac   -    aacagg 

Annotation confidence Not enough data

Genome context

chr11: 118910708-118910787 [+]

Disease association

hsa-mir-4492 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4492

• Accession: MIMAT0019027
• Description: Homo sapiens hsa-miR-4492 mature miRNA
• Sequence: 58 - GGGGCUGGGCGCGCGCC - 74
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127