Accession
MI0016882
Symbol
HGNC:
MIR4516
Description
Homo sapiens
hsa-mir-4516 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4516 is a microRNA-coding gene that has been implicated in various diseases and biological processes. In a study on autism spectrum disorder (ASD), MIR4516 was identified as one of the candidate-susceptible miRNA-coding genes [PMC9906952]. In gastric cancer (GC), circRNA0047905 was found to bind MIR4516 and miR1227-5p, leading to the activation of the Akt/CREB signaling pathway and promoting disease progression [PMC8305186]. The levels of MIR4516 were found to be significantly associated with osteopaenia and osteoporosis in patients with low bone mineral density (BMD) who had experienced fractures [PMC5976644]. Furthermore, the levels of MIR4516 were decreased in plasma samples from osteoporotic patients compared to non-osteoporotic controls and osteopaenia patients [PMC5976644]. In a study on CD4 T cell latency, an increase in the levels of MIR4516 was observed upon treatment with CCL19 and IL-7, but inhibiting this microRNA did not reverse latency [PMC7926981]. Additionally, MIR4516 has been reported to be involved in regulating epithelial barrier function in intestinal and airway epithelium [PMC9128841]. The down-regulation of MIR4516 was observed along with other genes in various diseases such as autism spectrum disorder, multiple sclerosis, gastric cancer, and others [PMC8874170]. Overall, these findings highlight the potential role of MIR4516 as a biomarker or therapeutic target for various diseases.
Literature search
9 open access papers mention hsa-mir-4516
(78 sentences)
(78 sentences)
Sequence
417
reads,
147
reads per million, 51 experiments
aGGGAGAAGGGUCGGGGCagggagggcagggcaggcucugggguggggggucugugagucagccacggcucugcccacgucucccc
.((((((.(((.((((((.(((..(((...(((((((((.......)))))))))..)))..)).).)))))))))...)))))).
.((((((.(((.((((((.(((..(((...(((((((((.......)))))))))..)))..)).).)))))))))...)))))).
Structure
a --A U a - ag agg gg GGGAGA GGG CGGGGC g gg ggc gcaggcucu g |||||| ||| |||||| | || ||| ||||||||| g cccucu ccc gucucg c cc cug ugucugggg u c gca - g a ga -ag gg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr16: 2133119-2133204 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-4516
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-4516 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4516
| Accession | MIMAT0019053 |
| Description | Homo sapiens hsa-miR-4516 mature miRNA |
| Sequence | 2 - GGGAGAAGGGUCGGGGC - 18 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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