Accession
MI0016887
Symbol
HGNC:
MIR4521
Description
Homo sapiens
hsa-mir-4521 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4521 is a microRNA whose validity has been questioned, yet it has been identified as significantly upregulated in early diabetic nephropathy (DN) [PMC5340965, PMC7759603].. The expression of MIR4521 has been manipulated in experimental settings using a pre-miRNA sequence [PMC6754377]. Studies have shown that high levels of MIR4521 expression correlate with poor prognoses, suggesting its potential role as a biomarker [PMC7583989]. Additionally, MIR4521 is one of the microRNAs regulated by STAT3 that is overexpressed in HT29-derived tumorspheres, which are a model for cancer stem cells [PMC7583989]. In the context of diabetic kidney disease (DKD), MIR4521 is among the miRNAs identified as having vital roles in the disease's pathogenesis [PMC8183707].
Literature search
3 open access papers mention hsa-mir-4521
(6 sentences)
(6 sentences)
Sequence
213980
reads,
2192
reads per million, 77 experiments
ucgGCUAAGGAAGUCCUGUGCUCAGuuuuguagcaucaaaacuaggauuucucuuguuac
..(((.(((((((((((......(((((((......))))))))))))))).))))))..
..(((.(((((((((((......(((((((......))))))))))))))).))))))..
Structure
uc U - GUGCUC ua gGC AAG GAAGUCCU AGuuuug g ||| ||| |||||||| ||||||| uug uuc cuuuagga ucaaaac c ca - u ------ ua
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr17: 8186945-8187004 [+]
Disease association
hsa-mir-4521 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4521
| Accession | MIMAT0019058 |
| Description | Homo sapiens hsa-miR-4521 mature miRNA |
| Sequence | 4 - GCUAAGGAAGUCCUGUGCUCAG - 25 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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