miRBase entry: xtr-mir-449b

Stem-loop xtr-mir-449b

Accession

MI0018161

Description

Xenopus tropicalis xtr-mir-449b precursor miRNA

Sequence

accugcuuuggguAGGCAGUGUAGUUUUAGCUGGcugcuugcuauuaacuccagCAGUCGCUAAUACUCUGCCACCggcagcaggg
.((((((.(.(((.(((((.(((...(((((.(((((((.............))))))))))))))).)))))))).).)))))).

Structure

a      u g   A     U   GUU     U       ugcua 
 ccugcu u ggu GGCAG GUA   UUAGC GGcugcu     u
 |||||| | ||| ||||| |||   ||||| |||||||     u
 ggacga g CCA CCGUC CAU   AAUCG CUGACga     a
g      c g   -     U   ---     -       ccuca

Annotation confidence Not enough data

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Comments

Expression of the miR-449 family sequences is validated in X. laevis by SOLID sequencing [1].

Genome context

chr1: 178899727-178899812 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from xtr-mir-449b

Name	Accession	Chromosome	Start	End	Strand	Confidence

Database links

Mature xtr-miR-449b-5p

Accession	MIMAT0022745
Description	Xenopus tropicalis xtr-miR-449b-5p mature miRNA
Sequence	14 - AGGCAGUGUAGUUUUAGCUGG - 34
Evidence	not_experimental

Mature xtr-miR-449b-3p

Accession	MIMAT0022746
Description	Xenopus tropicalis xtr-miR-449b-3p mature miRNA
Sequence	55 - CAGUCGCUAAUACUCUGCCACC - 76
Evidence	not_experimental

References

PubMed ID: 21602795
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
"Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P"
"Nat Cell Biol (2011) 13:693-699