miRBase entry: xtr-mir-449c

Stem-loop xtr-mir-449c

Accession

MI0018162

Description

Xenopus tropicalis xtr-mir-449c precursor miRNA

Sequence

aaguuuggaccaaugAGGCAGUGCACUUGCUAGCUGGCUGUuguguucuggaagcuuacAGCUGCUAGCUGCACUCCACAuuguuucauucug
.((..((((.(((((.((.((((((...((((((.((((((...(((.....)))..)))))))))))))))))))).))))).))))..)).

Structure

a  uu    c     A  C      CUU      U      ugu   c 
 ag  ugga caaug GG AGUGCA   GCUAGC GGCUGU   guu u
 ||  |||| ||||| || ||||||   |||||| ||||||   ||| g
 uc  acuu guuAC CC UCACGU   CGAUCG UCGAca   cga g
g  uu    u     A  -      ---      -      -uu   a

Annotation confidence Not enough data

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Comments

Expression of the miR-449 family sequences is validated in X. laevis by SOLID sequencing [1].

Genome context

chr1: 178899485-178899577 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from xtr-mir-449c

Name	Accession	Chromosome	Start	End	Strand	Confidence

Database links

Mature xtr-miR-449c-5p

Accession	MIMAT0022747
Description	Xenopus tropicalis xtr-miR-449c-5p mature miRNA
Sequence	16 - AGGCAGUGCACUUGCUAGCUGGCUGU - 41
Evidence	not_experimental

Mature xtr-miR-449c-3p

Accession	MIMAT0022748
Description	Xenopus tropicalis xtr-miR-449c-3p mature miRNA
Sequence	60 - AGCUGCUAGCUGCACUCCACA - 80
Evidence	not_experimental

References

PubMed ID: 21602795
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
"Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P"
"Nat Cell Biol (2011) 13:693-699