Accession
MI0000077
Symbol
HGNC:
MIR21
Description
Homo sapiens
hsa-mir-21 precursor miRNA mir-21
Gene
family?
family?
RF00658;
mir-21
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR21 is an oncogenic microRNA implicated in various cellular processes, including wound healing and cancer pathogenesis [PMC7053209, PMC5863695].'>PMC5863695].. In the context of non-small cell lung cancer (NSCLC), serum MIR21 levels are significantly elevated in patients compared to controls and are associated with advanced TNM stages [PMC4737022]. MIR21, along with CYFRA21-1, has been identified as a potential serum marker for the early diagnosis of NSCLC, with joint detection of these markers enhancing diagnostic efficiency [PMC4737022]. Moreover, MIR21 has been shown to confer resistance to heat shock protein 90 (HSP90) inhibitors in cancer cells by modulating the expression of HSP40 [PMC5863695]. Inhibition of MIR21 can restore sensitivity to HSP90 inhibitors, suggesting its potential as a biomarker for treatment response [PMC5863695]. Additionally, increased MIR21 abundance during oocyte maturation is associated with posttranscriptional regulation of programmed cell death 4 (PDCD4) expression and may affect embryonic development [PMC4833929]. Overall, these findings highlight the multifaceted role of MIR21 in disease processes and its utility as a biomarker for diagnosis and treatment response.
Literature search
1559 open access papers mention hsa-mir-21
(13078 sentences)
(13078 sentences)
Sequence
6832853
reads,
24235
reads per million, 159 experiments
ugucgggUAGCUUAUCAGACUGAUGUUGAcuguugaaucucauggCAACACCAGUCGAUGGGCUGUcugaca
((((((((((((((((.(((((.(((((.((((.((...))))))))))).)))))))))))))))))))))
((((((((((((((((.(((((.(((((.((((.((...))))))))))).)))))))))))))))))))))
Structure
A A A u a
ugucgggUAGCUUAUC GACUG UGUUG cugu ga
|||||||||||||||| ||||| ||||| |||| || u
acagucUGUCGGGUAG CUGAC ACAAC ggua cu
- C - - c
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
Mourelatos et al. named this sequence miR-21 precursor-17 and also reported the exact reverse complement of this predicted stem-loop sequence and erroneously assigned the name miR-104 [2].
Genome context
chr17: 59841266-59841337 [+]
Disease association
hsa-mir-21 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-21 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-21 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-21-5p
| Accession | MIMAT0000076 |
| Description | Homo sapiens hsa-miR-21-5p mature miRNA |
| Sequence | 8 - UAGCUUAUCAGACUGAUGUUGA - 29 |
| Evidence |
experimental
cloned [1-3,6-9], Northern [1,5], Illumina [10] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-21-3p
| Accession | MIMAT0004494 |
| Description | Homo sapiens hsa-miR-21-3p mature miRNA |
| Sequence | 46 - CAACACCAGUCGAUGGGCUGU - 66 |
| Evidence |
experimental
cloned [8-9] |
| Database links |
|
| Predicted targets |
|
References
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