Stem-loop sequence hsa-mir-219a-1

Accession

MI0000296 (change log)

Previous IDs

hsa-mir-219

Symbol

HGNC:MIR219A1

Description

Homo sapiens miR-219a-1 stem-loop

Gene family

MIPF0000044; mir-219

Literature search

70 open access papers mention hsa-mir-219a-1
(248 sentences)

Stem-loop

   -    c --------c    c       cu   u     a  g         a   uau 
5'  ccgc c         gggc gcggcuc  gau gucca ac caauucucg guc   g
    |||| |         |||| |||||||  ||| ||||| || ||||||||| |||   g
3'  ggcg g         cccg cgccgag  cug caggu ug guugagagc cgg   c
   g    a cuccaaacc    c       cc   -     c  a         -   ccu 

Deep sequencing

2679 reads, 0 reads per million, 144 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the 5' excised miR has been validated in zebrafish, and the 5' end mapped by PCR [2]. The mature products were later validated in human [3]. Two hairpin precursor structures are predicted, mir-219-1 on chromosome 6 (MI0000296) and mir-219-2 on chromosome 9 (MI0000740) [2].

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr6: 33207835-33207944 [+]
• Overlapping transcripts:

  intergenic

Database links

• EntrezGene:MIR219-1
• HGNC:MIR219A1
• RNAcentral:URS0000173F7B_9606
• miRBase Tracker:MI0000296

Mature sequence hsa-miR-219a-5p

• Accession: MIMAT0000276
• Previous IDs: hsa-miR-219
• Sequence: 21 - ugauuguccaaacgcaauucu - 41
• Deep sequencing: 3742 reads, 132 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS0000565C8D_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-219a-5p
  • miRDB:hsa-miR-219a-5p
  • microrna.org:hsa-miR-219a-5p

Mature sequence hsa-miR-219a-1-3p

• Accession: MIMAT0004567
• Sequence: 62 - agaguugagucuggacgucccg - 83
• Deep sequencing: 699 reads, 91 experiments
• Evidence: experimental; cloned [3]
• Database links:
  • RNAcentral:URS00000BD1DE_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-219a-1-3p
  • miRDB:hsa-miR-219a-1-3p
  • microrna.org:hsa-miR-219a-1-3p

References

1. PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2. PMID:15634332 "New human and mouse microRNA genes found by homology search" Weber MJ FEBS J. 272:59-73(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).