Stem-loop mmu-mir-34c

Accession

MI0000403

Symbol

MGI: Mir34c

Description

Mus musculus mmu-mir-34c precursor miRNA mir-34

Gene
family

RF00456; mir-34

Literature search

228 open access papers mention mmu-mir-34c
(1443 sentences)

Sequence

5659980 reads, 29244 reads per million, 106 experiments

agucuaguuacuAGGCAGUGUAGUUAGCUGAUUGCuaauaguaccAAUCACUAACCACACAGCCAGGuaaaaagacu
(((((..(((((.(((.((((.(((((.((((((.((....)).))))))))))).)))).))).)))))..)))))

Structure

     ag     A   A    A     C      C  a 
agucu  uuacu GGC GUGU GUUAG UGAUUG ua u
|||||  ||||| ||| |||| ||||| |||||| ||  
ucaga  aauGG CCG CACA CAAUC ACUAAc au a
     aa     A   A    C     -      c  g 

Annotation confidence Medium

Comments

Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells [1], and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) and miR-34a (MIR:MI0000584) to clarify homology with human sequences.

Genome context

chr9: 51103034-51103110 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-34c

Mature mmu-miR-34c-5p

• Accession: MIMAT0000381
• Description: Mus musculus mmu-miR-34c-5p mature miRNA
• Sequence: 13 - AGGCAGUGUAGUUAGCUGAUUGC - 35
• Evidence: experimental ; cloned [1-3], Illumina [4-5]

Mature mmu-miR-34c-3p

• Accession: MIMAT0004580
• Description: Mus musculus mmu-miR-34c-3p mature miRNA
• Sequence: 46 - AAUCACUAACCACACAGCCAGG - 67
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


3. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


4. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


5. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009