Accession
MI0000552
Symbol
MGI:
Mir196a-1
Description
Mus musculus
mmu-mir-196a-1 precursor miRNA
Literature search
67 open access papers mention mmu-mir-196a-1
(596 sentences)
(596 sentences)
Sequence
184284
reads,
275
reads per million, 73 experiments
ugagccgggacuguugagugaagUAGGUAGUUUCAUGUUGUUGGGccuggcuuucugaacaCAACGACAUCAAACCACCUGAUucauggcaguuacugcuuc
.((((.(..((((((..(((((.(((((.((((.((((((((((..(.........)..).))))))))).)))).))))).)))))))))))..).)))).
.((((.(..((((((..(((((.(((((.((((.((((((((((..(.........)..).))))))))).)))).))))).)))))))))))..).)))).
Structure
u c gg ga g A C - Gc ugg gagc g acuguu gugaa UAGGU GUUU AUGUUGUUG G c c |||| | |||||| ||||| ||||| |||| ||||||||| | | u uucg c ugacgg uacuU GUCCA CAAA UACAGCAAC c g u c u au -- A C C a aa ucu
Annotation confidence
Medium
Do you think this miRNA is real?
Comments
Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr11: 96265164-96265265 [+]
Database links
Mature mmu-miR-196a-5p
| Accession | MIMAT0000518 |
| Description | Mus musculus mmu-miR-196a-5p mature miRNA |
| Sequence | 24 - UAGGUAGUUUCAUGUUGUUGGG - 45 |
| Evidence |
experimental
cloned [1,3], Illumina [4-5] |
| Database links |
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| Predicted targets |
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Mature mmu-miR-196a-1-3p
| Accession | MIMAT0017013 |
| Description | Mus musculus mmu-miR-196a-1-3p mature miRNA |
| Sequence | 62 - CAACGACAUCAAACCACCUGAU - 83 |
| Evidence |
experimental
454 [5], Illumina [6] |
| Database links |
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| Predicted targets |
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References
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